Mechanistic Investigation on the Antibacterial Activity of Biogenic Silver Nanoparticles Prepared Using Root Extract of Sarsaparilla and Demonstrated their In Vivo Efficacy in Zebrafish Model.

Antibiotic success rates are decreasing as drug-resistant bacteria become more prevalent, prompting the development of new therapeutic drugs. Herein, we demonstrated the antimicrobial activity of sarsaparilla root extract fabricated silver nanoparticles (sAgNPs). The UV-Visible spectra revealed that the surface Plasmon resonance maxima of sAgNPs were at 415 nm.

Correction: Platinum nanoparticles inhibit bacteria proliferation and rescue zebrafish from bacterial infection.

[This corrects the article DOI: 10.1039/C6RA03732A.].

Receptor-free phenothiazine derivative as fluorescent probe for picric acid: Investigation of the inner filter effect channel.

In this study, a highly fluorescent and receptor-free phenothiazine derivative (PDAB) was developed to detect picric acid. A combination of steady-state and time-resolved fluorescence studies was conducted to examine the excited state behavior of PDAB with picric acid in solution. The PDAB probe displayed a significant degree of selectivity and was highly sensitive to picric acid, with an extremely low detection limit of 9.

Green Synthesis of ZnO and V-Doped ZnO Nanoparticles Using Vinca rosea Plant Leaf for Biomedical Applications.

The present work focused on the synthesis of Vinca rosea leaf extract derived ZnO and vanadium-doped ZnO nanoparticles (V-ZnO NPs). The chemical composition, structural, and morphology of ZnO and vanadium-doped ZnO NPs were examined by FTIR, XRD, and SEM-EDX. The FTIR confirmed the presence of functional groups corresponding to ZnO and vanadium-doped ZnO NPs.

Hybrid of Metapenaeus dobsoni lectin and platinum nanoparticles exert antimicrobial and immunostimulatory effects to reduce bacterial bioburden in infected Nile tilapia.

A novel antibacterial immunostimulant using Platinum nanoparticles (PtNPs) and lectin from Metapenaeus dobsoni (Md-Lec) was developed. The Md-Lec and PtNPs (Pt-lec) hybrid formed through non-covalent interaction exhibits antimicrobial activity against fish specific pathogens by affecting membrane integrity and producing excess reactive oxygen species. The therapeutic efficacy of Pt-lec was demonstrated through rescuing Aeromonas hydrophila infected Nile Tilapia.

Activity of lipid-loaded lectin against co-infection of Candida albicans and Staphylococcus aureus using the zebrafish model.

Aim: Nosocomial infection caused by mixed species of methicillin-resistant Staphylococcus aureus (MRSA) and Candida albicans (CA) is difficult to manage with existing antimicrobials, particularly in the presence of mixed-species biofilm. This study evaluates the activity of cationic lipid, specifically functionalized with lectin, against mixed biofilms of MRSA and CA and their effectiveness in vivo using the zebrafish model.

Methods And Results: The present study demonstrates for the first time the antimicrobial activity of 2-((N-[2-hydroxyethyl]palmitamido)methyl)-1-methylpyridin-1-ium iodide (cN16E) against MRSA and mixed species of MRSA + CA.

Antiproliferative Activity of Green Synthesised Silver Nanoparticles of Cassia Marginata Roxb.

Green synthesised silver nanoparticles (AgNPs) have been identified as a promising new therapy pathway for cancer because of their anti-angiogenic potency. In the present study, CM-AgNPs were biosynthesized using aqueous leaf extract of Cassia marginata Roxb (CM) and were confirmed by spectral studies like UV-Visible and attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopic techniques. The structure and shape of the biosynthesized CM-AgNPs were confirmed by scanning electron microscope (SEM), energy-dispersive spectroscopy (EDX), and high-resolution transmission electron microscopy (HR-TEM) with selected area electron diffraction (SAED) studies.

Anti-Dengue Activity of ZnO Nanoparticles of Crude Fucoidan from Brown Seaweed S.marginatum.

Dengue fever is a rapidly spreading infection that affects people all over the tropics and subtropics, posing a significant public health threat. The brown seaweed Stoechospermum marginatum was found all over the world, from South Africa (Indian Ocean) to Australia (Pacific Ocean), among other places. In India, it is only available along the coast of the Bay of Bengal, which is a small region.

Green route synthesis of ZnO nanoparticles using Senna auriculata aqueous flower extract as reducing agent and evaluation of its antimicrobial, antidiabetic and cytotoxic activity.

The nanoparticles have unique and superior properties which make them applicable in almost every field of human life. Among the various methods that exist for the synthesis of nanoparticles, green synthesis is one of the best economic and eco-friendly methods compared with other conventional chemical methods. The nanoparticles synthesized by this method are also free from toxicity properties.

Avian feathers as a biomonitoring tool to assess heavy metal pollution in a wildlife and bird sanctuary from a tropical coastal ecosystem.

In this study, we have assessed the concentrations of four heavy metals (Cu, Zn, Cd, and Pb) in the feathers of 11 species of birds from the Point Calimere Wildlife and Bird Sanctuary, a protected environment. Concentrations of copper and zinc were detected in all the bird species, cadmium was observed only in two bird species, and lead was below the detection limits for all birds. The order of concentration of metals in the feathers is Zn > Cu > Cd > Pb.

Health risk assessment and bioaccumulation of metals in brown and red seaweeds collected from a tropical marine biosphere reserve.

In the present study, we have assessed the degree of contamination of heavy metals (Cd, Cu, Pb, and Zn) in ten species of red and brown seaweeds, the seasonal variations in the concentration of metals, and the health risk due to the seaweeds. Overall metal concentrations for red and brown seaweeds followed the order Pb > Zn > Cu > Cd and Pb > Cu > Zn > Cd, respectively. Cd and Pb levels were found to be elevated in both the red and brown seaweeds.

Targeting the glycan of receptor binding domain with jacalin as a novel approach to develop a treatment against COVID-19.

analysis revealed that a lectin, jacalin from jackfruit seeds, recognizes a glycosylated region of the receptor-binding domain (RBD) of SARS-CoV2. Jacalin binding induces conformational changes in RBD and significantly affects its interaction with human angiotensin-converting enzyme 2. The result may open up exploration of lectin-based strategies against COVID-19.

A study on the interaction of nile blue with Uracils: A spectroscopic and computational approach.

The present work focuses the investigation on fluorescence quenching of nile blue (NB) in presence of various substituted uracil molecules. UV-Visible absorption studies signify the possibility of ground state complex formation between NB and uracil molecules. The increase in concentration of quencher molecules greatly influences the emission spectra of NB.

Maximizing the direct recovery and stabilization of cellulolytic enzymes from Trichoderma harzanium BPGF1 fermented broth using carboxymethyl inulin nanoparticles.

The carboxymethylated inulin (CMI) nanoparticles prepared by the salt out method was demonstrated to harvest cellulolytic enzymes (Ez) directly from the clarified fermented broth of Trichoderma harzanium BPGF1. The formation of CMI nanoparticles and entrapment of Ez in CMI was confirmed by scanning electron microscopy and Fourier transform infrared spectroscopy, respectively. A factorial design was developed to maximize enzymes recovery directly from the fermented broth.

Revealing the Significance of the Glycan Binding Property of Seed Lectin for Enhancing the Antibiofilm Activity of Silver Nanoparticles against Uropathogenic .

The incompetence of conventional antibiotics against bacteria residing in biofilms demands newer therapeutic intervention. In this study, we demonstrated that the interaction between silver nanoparticles (AgNPs) and seed lectin (BMSL) forms efficient surface-functionalized AgNPs with excellent antibiofilm competency against uropathogenic (UPEC). The minimum biofilm inhibitory concentration (MBIC) of AgNPs and the BMSL-AgNP conjugate (BAgNP) against UPEC was 75 and 9.

A functional Ag-TiO nanocomposite solar selective absorber with antimicrobial activity by photochemical reduction process.

A functional nanocomposite coating developed by wet chemical route in a photochemical reduction process will be a good candidate for low temperature solar thermal application. The low-temperature curable cermet comprises of two different type of nanoparticles, generated by photocatalytic reduction of silver ions under the sunlight with the aid of crystalline TiO (~8 nm) nanoparticles. The optimized base absorber layer of Ag-TiO nanocomposite exhibited absorptance (α) of 0.

Remarkable Effect of Jacalin in Diminishing the Protein Corona Interference in the Antibacterial Activity of Pectin-Capped Copper Sulfide Nanoparticles.

Herein, we report a new strategy based on jacalin functionalization to diminish the impact of biological fluids in the antibacterial applications of nanoparticles (NPs). Precoating pectin-capped copper sulfide NPs (pCuS) with bovine serum albumin produced a protein corona, which affects the antibacterial activity of pCuS. It was found that the minimum inhibitory concentration (MIC) increases fourfold because of the formation of the protein corona.

Evaluation of the toxicities of silver and silver sulfide nanoparticles against Gram-positive and Gram-negative bacteria.

In this study, the endogenous lipid signalling molecules, -myristoylethanolamine, were explored as a capping agent to synthesise stable silver nanoparticles (AgNPs) and Ag sulphide NPs (AgS NPs). Sulphidation of the AgNPs abolishes the surface plasmon resonance (SPR) maximum of AgNPs at 415 nm with concomitant changes in the SPR, indicating the formation of AgS NPs. Transmission electron microscopy revealed that the AgNPs and AgS NPs are spherical in shape with a size of 5-30 and 8-30 nm, respectively.

Simple admixture of 4-nitrobenzaldehyde and 2,4-dimethylpyrrole for efficient colorimetric sensing of copper(II) ions.

An easily accessible chemo-probe based on physical mixture of 2,4-dimethylpyrrole and 4-nitrobenzaldehyde has been developed. Based on NMR spectroscopic analysis, catalyst free formation of dipyrromethane was observed in the physical mixture of chemo-probe. The probe is utilized in effective colorimetric sensing of copper(II) ions present in environmental solutions by instantaneous appearance of red colour, even in the co-existence of various metal ions.

Facile synthesis of gold nanoparticles using carbon dots for electrochemical detection of neurotransmitter, dopamine in human serum and as a chemocatalyst for nitroaromatic reduction.

Herein, the authors reported a carbon dots mediated synthesis of gold nanoparticles (AuNPs) at room temperature. Transmission electron microscopy revealed that the AuNPs are spherical in shape with a size of 10 nm. As-prepared AuNPs was immobilised on carbon paste electrode and subjected to electrochemical sensing of an important neurotransmitter dopamine.

Analysis and assessment of heavy metals in soils around the industrial areas in Mettur, Tamilnadu, India.

Industrialization and extraction of natural resources have resulted in large-scale environmental contamination and pollution. We have collected the soil samples from five different industrial areas of Mettur (Chemplast Sanmar Limited, SIDCO-1, SIDCO-2, SIDCO-3, thermal power plant), Salem district, Tamil Nadu, India, and estimated the physical properties (pH, EC, and alkalinity), chemical properties (major and minor elements), and heavy metal analysis. Thermal power plant soil sample showed higher pH 5.

Preparation of self-assembled platinum nanoclusters to combat Salmonella typhi infection and inhibit biofilm formation.

In this work, phytoprotein functionalized platinum nanoparticles (PtNCs) were synthesized using the proteins from fresh green spinach leaves. Transmission electron microscopy showed that PtNCs were spherical shape with size ∼5 nm, which self assembled into spherical platinum nanoclustures (PtNCs) with size within the range of 100-250 nm. The presence of elemental platinum was confirmed by EDX analysis.

C-H oxidation and chelation of a dipyrromethane mediated rapid colorimetric naked-eye Cu(ii) chemosensor.

Copper(ii) ion mediated C-H oxidation of dipyrromethanes (DPMs) to the corresponding dipyrrins followed by complexation invoked the selective sensing of copper(ii) ions in aqueous solutions. On the addition of copper, the colour of the DPM solution instantaneously changes from yellow to pink with the detection limit of 0.104 μM measured by absorption spectroscopy, whereas visible colour changes could be observed by the naked eye for concentrations as low as 3 μM.