Publications by authors named "Anbang Liu"
Background: The global aging trend exacerbates the challenge of frailty and cognitive impairment in older adults, yet their combined impact on health outcomes remains under-investigated. This study aims to explore how frailty and psychometric mild cognitive impairment (pMCI) jointly affect all-cause and cardiovascular disease (CVD) mortality.
Methods: The cohort study we examined 2,442 participants aged ≥ 60, is the secondary analysis from the National Health and Nutrition Examination Survey (NHANES) 2011-2014.
Associations of the Charlson comorbidity index with depression and mortality among the U.S. adults.
Front Public Health
December 2024
Background: Chronic comorbidities are often associated with higher risks of depression and mortality. This study aims to explore the relationships between the Charlson Comorbidity Index (CCI) and depression, and their combined effect on mortality.
Methods: This study made use of data gathered in the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018, including a collective of 23,927 adult participants.
Article Synopsis
- Mental stress-induced myocardial ischemia (MSIMI) significantly increases cardiovascular events, yet its precise mechanisms related to myocardial blood flow (MBF) are not fully understood.
- A study using cardiac positron emission tomography (PET-CT) revealed that women with angina but no obstructive coronary artery disease (ANOCA) had a much higher prevalence of MSIMI compared to healthy controls.
- Results showed that these participants had lower MBF and coronary flow reserves, indicating that impaired coronary microvascular function plays a crucial role in the development of MSIMI in individuals with ANOCA.
Article Synopsis
- Depression and high-sensitivity C-reactive protein (hs-CRP) are linked to worse outcomes in coronary heart disease (CHD) patients, but their combined effects had not been well-studied before this research.
- The study assessed 414 CHD patients over two years using tools to measure depression and anxiety, finding that those with both elevated depression and high hs-CRP faced significantly higher risks of noncardiac readmissions and other adverse events.
- While high hs-CRP alone was associated with increased risks, elevated anxiety did not significantly impact patient outcomes, and no interactions between depression or anxiety and hs-CRP were found.
Background: The cardiometabolic index (CMI) is a novel metric for assessing cardiometabolic health and type 2 diabetes mellitus (DM), yet its relationship with insulin resistance (IR) and prediabetes (preDM) is not well-studied. There is also a gap in understanding the nonlinear associations between CMI and these conditions. Our study aimed to elucidate these associations.
View Article and Find Full Text PDFBackground: As hypertensive heart disease (HHD) presents a significant public health challenge globally, we analysed its global, regional, and national burdens and trends from 1990 to 2019.
Methods: We used data from the Global Burden of Disease (GBD) 2019 study, focussing on the age-standardised prevalence rates (ASPRs) of HHD prevalence, age-standardised disability-adjusted life year (DALY) rates, average annual percentage change (AAPC), and risk factor attributions. We compared the HHD burden across sociodemographic index (SDI) strata, gender, age groups, and 204 countries and territories.
Background: Metabolic syndrome (MetS) is a risk factor for cardiovascular disease (CVD), and CVD is a major challenge for cancer patients. This study aimed to investigate the prevalence and association of MetS and CVD among adult cancer patients.
Methods: This cross-sectional study included cancer patients aged > 18 years from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018.
Article Synopsis
- M2 tumor-associated macrophages (M2 TAM) significantly influence tumor invasion and metastasis through angiogenesis in lung adenocarcinoma (LUAD).
- Researchers identified 12 key genes related to M2 TAM and angiogenesis, which were used to create and validate a prognostic signature for LUAD patients.
- The study found that this signature correlates with immune response markers and tumor characteristics, providing insights into new treatment strategies for LUAD.
Background: Observational studies have reported an association between body mass index (BMI) as well as height and the risk of pneumothorax. However, it has long been unclear whether BMI or height are causally associated with pneumothorax.
Methods: Genetic summary data for BMI, height and pneumothorax were retrieved from multiple independent large genome-wide association studies (GWAS).
Background: Metabolic syndrome (MetS) is a pathological condition characterized by the abnormal clustering of several metabolic components and has become a major public health concern. We aim to investigate the potential link of Systemic immunity-inflammation index (SII) on MetS and its components.
Methods And Result: Weighted multivariable logistic regression was conducted to assess the relationship between SII and MetS and its components.
Breast cancer is the predominant cancer among women worldwide, and chemotherapeutic agents, such as doxorubicin (DOX), have the potential to significantly prolong survival, albeit at the cost of inducing severe cardiovascular toxicity. Inflammation has emerged as a crucial biological process contributing to the remodeling of cardiovascular toxicity. The role of serum glucocorticoid kinase 1 (SGK1) in various inflammatory diseases has been extensively investigated.
View Article and Find Full Text PDFTamoxifen induced cardiac damage via the IL-6/p-STAT3/PGC-1α pathway.
Int Immunopharmacol
December 2023
Tamoxifen (TAM) is an effective anticancer drug for breast and ovarian cancer. However, increased risk of cardiotoxicity is a long-term clinical problem associated with TAM, while the underlying mechanisms remain unclear. Here, we performed experiments in cardiomyocytes and tumor-bearing or nontumor-bearing mice, and demonstrated that TAM induced cardiac injury via the IL-6/p-STAT3/PGC-1α/IL-6 feedback loop, which is responsible for reactive oxygen species (ROS) accumulation.
View Article and Find Full Text PDFIntroduction: Due to the cardiotoxicity of cancer treatment and traditional risk factors for cardiovascular disease (CVD) such as obesity, diabetes, dyslipidemia, and hypertension, cancer patients are at higher risk of developing CVD. However, limited research exists on the correlation between chronic kidney disease (CKD) and CVD risk in cancer patients.
Methods: This cross-sectional study selected cancer patients aged ≥20 years from the National Health and Nutrition Examination Survey (NHANES) conducted from 2015 to 2020.
Article Synopsis
- Parkinson's disease (PD) is the second most common neurodegenerative disease, and the study explores keystroke biometrics as a method for early diagnosis by analyzing unique typing behaviors.
- Researchers evaluated various typing parameters, including alternating-finger tapping and interkey latencies, finding significant differences between de novo PD patients and healthy individuals, with high sensitivity rates for distinguishing between the two groups.
- The study concludes that keystroke biometrics can effectively screen for early PD, and typing speed along with the number of words typed may provide important insights into the clinical status of PD patients.
Prognosis value of EAS index in patients with obstructive coronary artery disease.
Quant Imaging Med Surg
September 2023
Article Synopsis
- The study investigates the effectiveness of the EAS index as a way to predict major adverse cardiovascular events (MACE) among patients with coronary artery disease (CAD), alongside traditional measures like left ventricular ejection fraction (LVEF).
- Researchers analyzed data from 477 CAD patients and found that a higher EAS index is linked to a greater risk of experiencing MACE within six months.
- Findings suggest that the EAS index could serve as a valuable tool for assessing risk in CAD patients, particularly for those with better cardiac function (LVEF ≥50%).
The role of long noncoding RNAs (lncRNAs) has been verified by more and more researches in recent years. However, there are few reports on cellular senescence-associated lncRNAs in lung adenocarcinoma (LUAD). Therefore, to explore the prognostic effect of lncRNAs in LUAD, 279 cellular senescence-related genes, survival information and clinicopathologic parameters were derived from the CellAge database and The Cancer Genome Atlas (TCGA) database.
View Article and Find Full Text PDFObjective: The aim of this study was to explore the different predictive values of depression among patients with different cardiac systolic function levels.
Methods: Four hundred eighty-three consecutive patients with obstructive coronary artery disease (CAD) were included the depressive state was assessed using the Chinese version of the Patient Health Questionnaire 9 (PHQ-9). Depression was defined as have depressive symptoms with a PHQ-9 score ≥5.
Background: Hypertensive patients with depression have a higher mortality rate and a worse prognosis compared with hypertensive only. Depression may reduce medication adherence in hypertension patients.
Methods: This study includes respondents in the National Health and Nutritional Examination Survey (NHANES) database from 2005 to 2018 who had previously been diagnosed with hypertension.
Background Patients with type A aortic dissection (TAAD) have a high short-term risk of stroke. However, whether patients with TAAD have an increased long-term risk of stroke is still undetermined, and our study aims to address this knowledge gap. Methods and Results A nationwide retrospective cohort study was conducted using Taiwan's National Health Insurance Research Database.
View Article and Find Full Text PDFBackground: Atrial fibrillation detected after stroke (AFDAS) has a lower risk of ischemic stroke recurrence than known atrial fibrillation (KAF). While the benefit of oral anticoagulants (OAC) for preventing ischemic stroke recurrence in KAF is well established, their role in patients with AFDAS is more controversial. This study aimed to evaluate the association between OAC use and the risk of recurrent ischemic stroke in patients with AFDAS in a real-world setting.
View Article and Find Full Text PDFBackground: Red blood cell distribution width (RDW) is associated with cardiovascular mortality. However, the relationship between preoperative RDW and outcomes after thoracic endovascular aortic repair (TEVAR) in type B aortic dissection (TBAD) remains to be determined.
Methods: We review the records of 678 patients with TBAD and treated with TEVAR in three centers.
Article Synopsis
- Cardiac autonomic neuropathy (CAN) is a common complication of diabetes that can be assessed through heart rate variability (HRV) and baroreflex sensitivity (BRS) related to blood pressure and heart rhythms.
- A new parameter, multiscale cross-approximate entropy (MS-CXApEn), was introduced to analyze the nonlinear relationship between systolic blood pressure (SBP) and ECG R-R intervals (RRIs) in male rats with diabetes and controls.
- Results showed that MS-CXApEn effectively identified changes in early diabetes progression, with higher values in hyperglycemic diabetic rats compared to controls, indicating its potential for early detection and assessment of CAN.
Aim: Exploring the risk factors of prognosis in patients undergoing percutaneous coronary intervention (PCI) is of great importance. Our aim of the study is to investigate the association between variability in total cholesterol (TC) level and major adverse cardiovascular and cerebrovascular events (MACCE) in patients after PCI.
Methods: Between April 2004 and December 2009, 909 patients who underwent primary PCI and with at least three TC values were included in the final study.
Background: The coexistence of depression and chronic diseases can lead to greater disability and increased mortality. The objective of this study was to examine the association between Dietary Inflammatory Index (DII) and depression in patients with chronic diseases and comorbidity.
Methods: Multivariable logistic regression analysis was used to investigate the relationship between DII and depression.
Article Synopsis
- The study aimed to explore the link between perceived stress and coagulation function in patients with coronary heart disease (CHD) and assess their impact on clinical outcomes.
- It used the Perceived Stress Scale (PSS-10) to evaluate stress levels and measured coagulation factors like APTT, finding that higher stress scores were associated with shorter APTT times.
- Results suggest that perceived stress and APTT can predict cardiovascular outcomes, indicating that mental stress may influence coagulation and contribute to cardiovascular events in CHD patients.*