Low AS160 and high SGK basal phosphorylation associates with impaired incretin profile and type 2 diabetes in adipose tissue of obese patients.

Objective: To compare basal insulin and mTOR signaling in subcutaneous fat of obese T2DM vs. obese subjects with normal glucose tolerance (NGT), and correlate it with clinical parameters of carbohydrate metabolism and incretin secretion profiles.

Methods: Recruited were 22 patients with long (>10 years) and morbid (BMI > 35 kg/m) obesity, 12 of which had NGT and 10 had T2DM.