Synthesis, characterization and pre-clinical evaluation of (99m) Tc-tricarbonyl complexes as potential myocardial perfusion imaging agents.

Myocardial perfusion imaging is an established Nuclear Medicine investigation. Current myocardial perfusion imaging agents sestamibi and tetrofosmin have number of drawbacks; low heart uptake coupled with uptake into the surrounding tissues leads to a poorer image quality. There is a need for continued research into designing and evaluating potentially superior myocardial imaging agents.

Etiology of child acute stiff neck.

Study Design: The results of MRI study of 10 children with acute stiff-neck who were treated in the Department of Spine Surgery in Saint-Petersburg State Pediatric Medical Academy.

Objectives: To demonstrate the MRI findings in children with acute stiff neck and suggest other explanations to this findings.

Summary Of Background Data: The etiology of child's acute stiff-neck has been debated in the published data.

Evaluation of 99mTc(CO)5I as a potential lung perfusion agent.

Introduction: The use of (99m)Tc-macroggregated albumin for lung perfusion imaging is well established in nuclear medicine. However, there have been safety concerns over the use of blood-derived products because of potential contamination by infective agents, for example, Variant Creutzfeldt Jakob Disease. Preliminary work has indicated that Tc(CO)(5)I is primarily taken up in the lungs following intravenous administration.