Publications by authors named "Anatoliy S Vinokurov"
Background: High burden of drug-resistant (DR) tuberculosis (TB) is a significant threat to national TB control programs all over the world and in the Russian Federation. Different Mycobacterium tuberculosis (MTB) genotypes are hypothesized to have specific characteristics affecting TB control programs. For example, Beijing strains are supposed to have higher mutation rates compared to strains of other genotypes and subsequently higher capability to develop drug-resistance.
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- A study involving 5,340 residents of Moscow investigated the relationship between immune responses (antibodies and T cells) to SARS-CoV-2 and the likelihood of COVID-19 infection.* -
- Results showed that individuals with both high T-cell and antibody responses had the lowest risk of infection, while those with only an antibody response also had a strong protective effect.* -
- The findings highlight that antibody responses are more crucial for protection against SARS-CoV-2 compared to T-cell responses, suggesting potential implications for public health policies related to COVID-19.*
Article Synopsis
- The study investigates the virulence of two clinical strains of the Beijing genotype associated with drug-resistant tuberculosis in C57BL/6 mice, highlighting their correlation to global health issues.
- Strains 267/47 (pre-XDR) and 120/26 (MDR) showed differing survival rates in infected mice, with 10% and 40% survival, respectively, compared to 70% for the H37Rv strain.
- Comparison of immune responses revealed significant differences in cytokine gene expression, particularly with downregulated pro-inflammatory and anti-inflammatory genes in mice infected with the more virulent strain 267/47.