[Changes in the lymph nodes of adrenalectomized rats with staphylococcal poisoning].

Histological changes in lymph nodes and dynamics of 11-oxycorticosteroid levels in blood were studied in intact and adrenalectomized rats under staphylococcal intoxication. At early stages (up to 24 h) after staphylotoxin or staphylococcal injection, stress reaction of the organism, which produces a rise of corticosteroid level in blood, was demonstrated to play the major role in aplasy of the lymphoid tissue. At later stages, when the level of corticosteroids decreases, the lymphoid tissue begins to restore.

[Bactericidal effect of cationic proteins of cellular origin on staphylococci].

A study was made of the bactericidal action of thymus histones, histone-like substance, from the nuclei of rabbit leukocytes and lysosomal cation proteins from the same leukocyte on different staphylococcus cultures. The majority of the strains of coagulasoneagative staphylococci perished under the effect of the preparations tested; cultures forming this enzyme retained their viability, irrespective of their virulence for mice, their capacity to the lecithinase formation and to mannite fermentation. The preparations studied possessed a different bactericidal activity.

[Hyaluronic capsule as one of the factors of hemolytic streptococcal pathogenicity].

Experiments were conducted on albino mice. It was shown that treatment of streptococci with testicular hyaluronidase or a single administration of the enzyme to infected animals failed to inhibit the infectious process. Injection of hyaluronidase solution to every 3 or 4 hours depressed the development of the process and increased the percentage of survived animals during its first stages.

[Changes in the lymphoid tissue and in the level of corticosteroids in staphylococcal intoxication and infection].

A complex quantitative study of changes of proliferative processes in lymphatic vessels on the one hand and changes of the level of corticosteroids in the peripheral blood in staphylococcal intoxication and infection in the same rats on the other hand has been carried out. In the work H3-thymidine has been used. The comparison of the obtained morphological data with the dynamics of the change in the corticosteroid level shows that the decay of lymphocytes, the devastating of light centers and the cortical substance of lymph nodes, an abrupt lowering of the amount of DNA-synthesizing and mitotically dividing cells take place in the period associated with a release of a great amount of corticosteroids into the blood.

[Discharge of myeloperoxidase from neutrophils during bacterial sorption].

A study was made of conditions and dynamics of discharge of myeloperoxidase (MPO) from rabbit neutrophils in case of encounter with staphylococci. The discharge began not later than 9--12 minutes after the administration of Staph. aureus into the neutrophil suspension, i.