Publications by authors named "Anastasiya O Novikova"

Article Synopsis
  • - Recent research highlights the repurposing of NMDA receptor antagonists like ketamine for treating major depressive disorder, sparking renewed interest in studying NMDA receptors.
  • - A study used whole-cell patch-clamp methods to evaluate the effects of biguanide compounds on NMDA receptors in rat hippocampal neurons, finding that certain compounds like cycloguanil, proguanil, and phenformin effectively inhibited these receptors.
  • - The compounds were found to act as non-competitive inhibitors, with distinct mechanisms, suggesting their potential for treating neurodegenerative disorders linked to glutamatergic excitotoxicity and providing insights into NMDA receptor structure.
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