Publications by authors named "Anastasius Damdimopoulos"
Article Synopsis
- Obesity leads to non-alcoholic fatty liver disease (NAFLD) by changing the regulatory networks and epigenomes in liver cells.
- The study shows that G protein pathway suppressor 2 (GPS2) plays a key role in these changes and hastens the transition from NAFLD to non-alcoholic steatohepatitis (NASH).
- Knocking out GPS2 in liver cells of mice reduces fat accumulation and fibrosis while activating genes that break down lipids, suggesting that the GPS2-PPARα relationship might be a potential target for therapy in NAFLD and NASH.
Macrophages play important roles in linking alterations of cholesterol metabolism and inflammation to the development of atherosclerosis. Previous studies have identified several positive and negative crosstalk mechanisms that connect cholesterol efflux and inflammation at the transcriptional level. Of particular relevance is that the expression of ATP-binding cassette transporter A1 ( Abca1), a main regulator of cholesterol efflux, can be induced by oxysterol receptor LXR agonists but also by bacterial endotoxins, such as LPS, that activate TLR4 signaling.
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