Effect of Diclofenac and Simvastatin on Bone Defect Healing-An In Vivo Animal Study.

Non-steroidal, anti-inflammatory drugs and statins are two widely prescribed drug classes that affect bone formation. The aim of this study was to elucidate the effect of diclofenac and simvastatin in artificial bone defect healing. One hundred and forty-four male Wistar rats were used, and the specimens were divided into groups, with respect to the route of drug administration and the type of defect healing (with or without collagen membrane), and subgroups, with respect to the study duration (2, 4 or 8 weeks).

Effect of clopidogrel in bone healing-experimental study in rabbits.

Background: Clopidogrel is a widely prescribed drug for prevention of myocardial infarction and stroke in patients at risk. It inhibits thrombus formation inhibition of the P2Y purinergic receptor on platelets, which is important in their activation by ADP. However, the P2Y receptor has also been found to be expressed in both osteoblasts and osteoclasts.

Alveolar ridge alterations in the maxillary anterior region after tooth extraction through orthodontic forced eruption for implant site development: a clinical CBCT study.

Objective: To investigate the effects of orthodontic forced eruption (OFE) with the straight-wire appliance in the dimensions of the alveolar process when used for extracting compromised maxillary anterior teeth and implant site development.

Material And Methods: Cone-beam computed tomography (CBCT) scans of 7 patients needing extraction of 17 maxillary anterior teeth were obtained before and immediately after OFE. Alveolar plate height and thickness measurements were performed on the buccal and palatal socket walls in CBCT sagittal cross sections.

Safety of dental extractions during uninterrupted single or dual antiplatelet treatment.

Optimal dental management in patients on long-term antiplatelet treatment is not clearly defined. Antiplatelet discontinuation increases the risk of thrombotic complications, whereas uninterrupted antiplatelet therapy, which is the currently recommended approach, is assumed to increase the bleeding hazard after dental procedures. We sought to prospectively compare the risk of immediate and late postextraction bleeding in patients receiving uninterrupted single or dual antiplatelet therapy.

Evaluation of peri-implant marginal bone loss using modified abutment connections at various crestal level placements.

The purpose of this study was to evaluate crestal bone loss around 282 two-piece implants with straight (n = 193) and platform-switched (n = 89) abutment connections after placement at various crestal levels. Implants were assigned into two groups according to straight and platform-switched abutment connections. Each group was further subdivided into three groups depending on the location (supracrestal, crestal, or subcrestal) of the implant cervical platform.

Incidence of impacted and supernumerary teeth-a radiographic study in a North Greek population.

Objectives: The aim of the present study was to investigate the prevalence of impacted and supernumerary teeth, apart from third molars.

Study Design: This was a retrospective study of 1.239 panoramic radiographs taken of patients who presented to the Department of Dentoalveolar Surgery, Implantology and Radiology at the School of Dentistry of the Aristotle University of Thessaloniki, Greece between 1991 and 1999.

Comparison of acceptance, preference, and efficacy between jet injection INJEX and local infiltration anesthesia in 6 to 11 year old dental patients.

Needleless devices have been developed to provide anesthesia without injections. Little controlled research has examined the acceptability of needleless devices in pediatric patients. The aims of the study were to compare children's acceptance and preference for one type of needleless jet injection with classical local infiltration as well as to evaluate the efficacy of the needleless anesthesia.

Evaluation of the osteogenic potential in experimental defects, with and without bone marrow, in the rabbit tibia: a pilot study.

Purpose: The influence of bone marrow in the osteogenic potential of bone has not been evaluated in the rabbit tibia model. Previous studies employed this model extensively to test the osteogenic capabilities of bone grafts. The primary aim of the present study was to assess the role of bone marrow in the healing of experimental defects in the rabbit tibia model.

A comparison of panoramic image quality between a digital radiography storage phosphor system and a film-based system.

Aim: To compare digital panoramic images acquired for the presurgical assessment of third molars captured with a storage phosphor-based system with conventional film panoramic radiographs.

Methods And Materials: A total of 51 pairs of digital and conventional panoramic images, made simultaneously, were included in this study. The images were evaluated for diagnostic quality prior to third molar surgery by two experienced oral surgeons and rated with a four-point grading scale.

Needle-less local anesthesia: clinical evaluation of the effectiveness of the jet anesthesia Injex in local anesthesia in dentistry.

Objectives: To clinically evaluate the jet injection Injex (Rösch AG Medizintechnik) using 2 different anesthetic solutions, and to compare the jet injection and the standard needle injection techniques.

Method And Materials: Of the 32 patients in the study, 10 received mepivacaine 3% anesthetic solution by means of the jet injection technique, while the remaining 22 patients received lidocaine 2% with epinephrine 1:80,000 by the same method. The 14 patients in whom pulp anesthesia was achieved were selected for an additional evaluation of the pulp reaction using standard needle injection anesthesia.

Osseointegration of Osseotite and machined-surfaced titanium implants in membrane-covered critical-sized defects: a histologic and histometric study in dogs.

The texture of an implant's surface can influence the rate and extent of bone fixation as expressed by the amount of linear bone-to-implant contact (BIC). The purpose of this study was to compare the bone density and linear BIC between Osseotite and machined-surface implants placed in bony defects without graft material and covered by a membrane. Thirty 2 mm diameter, 10 mm length custom implants were prepared for this study having a 'split surface,' with one side having the acid-etched surface and the opposite side having a machined surface.

The role of temperature in the action of mepivacaine.

The role of temperature in the action of local anesthetics was studied in 20 healthy young volunteers with plain 3% mepivacaine injected periapically twice in their maxillary first premolar, the first time with the solution at a temperature of 20 degrees C and the second time at 4 degrees C. The pulpal response was measured with a pulp tester every minute. The onset of pulp anesthesia was found to be of no statistical difference between 20 degrees C and 4 degrees C.

Bone regeneration around implants using spherical and granular forms of bioactive glass particles.

Purpose: It has been reported that previous Biogran (3i Implant Innovations, Inc., Palm Beach Gardens, FL) can be converted in vitro into hydroxyapatite (Biogran II) to accelerate new bone formation. The purpose of this study was to evaluate the bone regeneration around implants placed in critical-sized defects in rabbit tibia using granular and spherical forms of Biogran II in regards to implant contact, bone-to-graft contact, bone graft area, and total bone volume.

The role of temperature in the action of local anesthetics: a double study in vitro and in vivo.

The purpose of this study was the examination of the role of temperature in the action of lidocaine via electrophysiological recordings on the sciatic nerve of the rat in vitro and in vivo. 20 Male Wistar rats were used in each type of experiment. In vitro, lidocaine shows no statistically significant difference regarding the onset of anesthesia but at the temperature of 25 degrees C it is significantly more potent on the establishment of anesthesia compared to the temperature of 36.

Clinical evaluation of immediate loaded upper anterior single implants.

Among the guidelines to be followed in the selection of patients who are suitable for treatment with dental implants, there must be accurate assessment and evaluation of the factors that will lead to a functionally long-lasting and aesthetically pleasing result. The latter, which includes the maintenance and development of hard and soft tissues, undoubtedly presents a significant challenge in clinical implantology. The purpose of this study was the clinical evaluation of the methods currently available for the aesthetic restoration of the anterior maxilla using single implants that were loaded immediately.

Effect of autogenous harvest site location on the outcome of ridge augmentation for implant dehiscences.

Treatment planning for the placement of an implant in a site with a thin crestal ridge should address the probability that a buccal dehiscence will result. The aim of the present investigation was to perform guided bone regeneration (GBR) around implants with buccal dehiscences and evaluate the outcomes of using autogenous bone grafts harvested from three different intraoral sites. Forty-six Osseotite implants, 4 mm in diameter, were placed in thin crestal ridges, resulting in an uncovered implant surface from the buccal aspect.

Osseointegration of Osseotite and machined titanium implants in autogenous bone graft. A histologic and histomorphometric study in dogs.

It has been shown that a roughened implant surface results in a higher percentage of bone to implant contact (%BIC) than a machined one. A modified implant surface using a dual thermo-acid etching process (Osseotite) has been introduced and evaluated clinically, mechanically and histologically. The aim of the present study was the histological evaluation of the %BIC between the Osseotite or machined surfaces and the autogenous bone graft.