Publications by authors named "Anastasios Nikolaos Panagopoulos"
BACKGROUND Streptococcus pneumoniae is an uncommon but serious cause of infective endocarditis (IE), particularly in immunocompromised individuals, such as those with untreated HIV. When pneumococcal IE occurs, it is associated with high morbidity and mortality due to the high prevenance of complications such as acute valvular destruction and septic embolization. Therefore, early recognition and prompt surgical intervention are paramount to improving outcomes.
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- This study explored how a receptor called TREM-1 is involved in inflammation when cells are exposed to low shear stress, which mimics conditions that can contribute to heart disease.
- Researchers found that low shear stress increased TREM-1 expression and led to higher production of inflammatory substances, while high shear stress did not significantly impact TREM-1 levels.
- Inhibiting TREM-1 in cells exposed to low shear stress resulted in lower levels of inflammation, suggesting that targeting TREM-1 could be a potential therapy for atherosclerosis, needing further research in animal and human models.
Article Synopsis
- CABG is a surgical procedure for patients with serious coronary artery disease, and this study explores a new non-invasive way to assess blood flow dynamics before and after surgery.
- Using a computational platform, researchers tested two patients and found that their results matched well with traditional angiography measurements, validating the technology.
- The simulations showed that as blockage in a coronary artery worsens, the blood flow through the graft improves, indicating potential benefits of bypass surgery, although more clinical studies are needed to confirm these findings.