Insights on atherosclerosis by non-invasive assessment of wall stress and arterial morphology along the length of human coronary plaques.

Wall stress (WS) is associated with high arterial pressure and affects the localization of atherosclerotic lesions. We sought to non-invasively investigate the distribution of WS along the length of human coronary arteries and investigate its potential effect on atherosclerosis in association with vascular stiffness, local arterial curvature and plaque volume. We reconstructed three-dimensionally 28 coronary arteries from 22 subjects who had undergone coronary computed tomography angiography.

Differences in Stress Forces and Geometry between Left and Right Coronary Artery: A Pathophysiological Aspect of Atherosclerosis Heterogeneity.

Introduction: We sought to assess noninvasively the differences in hemorrheologic and geometric parameters between the left and right coronary artery (RCA). Low endothelial shear stress (ESS), high molecular viscosity (MV), and high wall stress (WS) induce atherosclerosis, while curvature and torsion have lately been implicated in the atherosclerotic process.

Methods: We studied 28 coronary arteries from 22 subjects undergoing coronary computed tomography angiography.

Association of remodeling with endothelial shear stress, plaque elasticity, and volume in coronary arteries: a pilot coronary computed tomography angiography study.

We sought to noninvasively assess the relationship between arterial remodeling, endothelial shear stress (ESS), and wall stiffness in coronary arteries. We studied 28 coronary arteries from 22 patients undergoing coronary computed tomography angiography (CCTA). The ESS was calculated in 2-mm long segments using computational fluid dynamics.