Publications by authors named "Anastasiia V Potapenko"
Article Synopsis
- The nitroglycerin (NTG) model is significant in migraine research, but its effects on intracranial vessels are not well understood.
- This study investigated how NTG influences blood flow in meningeal vessels of rats using imaging photoplethysmography (iPPG), focusing on amplitude changes in the iPPG waveform.
- Results showed that NTG caused varying effects on blood flow depending on pretreatment (saline vs. sumatriptan), indicating a complex interaction between NTG and blood vessel activity, with sumatriptan enhancing NTG's effects.
Transcranial Doppler ultrasonography is used to study intracranial blood flow changes associated with migraine in humans, but whether this method is helpful in preclinical settings is yet unknown. To identify changes in rat intracranial blood flow specific to trigeminovascular activation-a key process in migraine pathophysiology-we measured Doppler indices in the middle cerebral artery and basilar artery before, during, and after dural or somatosensory electrical stimulation. Hemodynamic changes specific to dural stimulation were tested further in separate experiments.
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