Publications by authors named "Anastasiadis K"

Article Synopsis
  • - Heart failure is characterized by high pressures in the heart and reduced blood output, presenting symptoms like congestion and perfusion issues, while cardiogenic shock reflects severe heart-related hemodynamic problems that lead to inadequate blood flow.
  • - Both heart failure and cardiogenic shock affect millions globally, come with poor prognoses, and significantly impact healthcare systems, often resulting from conditions like ischemic heart disease, hypertension, and cardiomyopathies.
  • - Understanding the various mechanisms and classifications of heart failure and cardiogenic shock is crucial for effective diagnosis and treatment, where a new classification system introduced in 2019 helps stratify patients by disease severity, improving decision-making regarding patient care.
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Inflammatory bowel disease (IBD) is an inflammatory clinical entity with many extraintestinal symptoms, including urinary tract manifestations. However, the bilateral ureteral obstruction is extremely rare. We report a case of bilateral ureteral obstruction in a 12-year-old male patient with ulcerative colitis (UC).

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Introduction: The ultimate answer to the question whether minimal invasive extracorporeal circulation (MiECC) represents the optimal perfusion technique in contemporary clinical practice remains elusive. The present study is a real-world study that focuses on specific perfusion-related clinical outcomes after cardiac surgery that could potentially be favourably affected by MiECC and thereby influence the future clinical practice.

Methods: The MiECS study is an international, multi-centre, two-arm randomized controlled trial.

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Βlunt trauma is a common injury in children; however, blunt abdominal aortic trauma is extremely rare and is accompanied by high rates of morbidity and mortality. We report our initial experience with the endovascular management of an abdominal aortic rupture in a 12-year-old boy after he was involved in a motor vehicle accident. The patient was a backseat-restrained passenger.

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Article Synopsis
  • The study aimed to investigate how different organic and inorganic acids affect the roughness, demineralization, and collagen structures of human dentin compared to traditional acids like phosphoric acid (PA) and EDTA.!
  • Using dentin discs, the researchers measured changes in roughness and collagen structures after treatment with various acids, finding that all treatments increased roughness, with PA causing the most significant changes.!
  • Results indicated that nitric acid (NA) led to the highest demineralization and altered collagen structures, while treatments with citric acid (CA) and EDTA had minimal effects, highlighting the importance of understanding these treatments for dental restorations.!
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Article Synopsis
  • Preeclampsia is a serious pregnancy-related condition characterized by high blood pressure, which can negatively impact fetal development.
  • It can lead to short-term issues for the fetus and long-term complications for newborns due to impaired blood flow during critical developmental stages.
  • The case presented involves a preterm baby who is small for their age, experiencing severe growth issues and gastrointestinal problems, born to a mother suffering from severe preeclampsia.
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Introduction: The trial hypothesized that minimally invasive extra-corporeal circulation (MiECC) reduces the risk of serious adverse events (SAEs) after cardiac surgery operations requiring extra-corporeal circulation without circulatory arrest.

Methods: This is a multicentre, international randomized controlled trial across fourteen cardiac surgery centres including patients aged ≥18 and <85 years undergoing elective or urgent isolated coronary artery bypass grafting (CABG), isolated aortic valve replacement (AVR) surgery, or CABG + AVR surgery. Participants were randomized to MiECC or conventional extra-corporeal circulation (CECC), stratified by centre and operation.

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Congenital recto-urethral fistula is the most common form of anorectal malformation found in boys. The final repair includes the ligation of the fistula and the anorectoplasty, and can be achieved either way: posterior sagitally or laparoscopically. We present a case of a term male infant diagnosed with anorectal malformation and recto-prostatic urethral fistula, that underwent a laparoscopic-assisted posterior sagittal anorectoplasty in our department.

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Introduction: Individualized heparin and protamine management is increasingly used as a strategy to reduce coagulation activation and bleeding complications. While it is associated with increased heparin requirements during Cardiopulmonary Bypass (CPB), the impact on protamine administration remains controversial. We aim to investigate the effect of heparin level-guided monitoring on protamine dosing during cardiac surgery where low-anticoagulation protocols are implemented.

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The purpose of the study was the investigation of the polymerization of a preheated composite resin beneath lithium disilicate. First, lithium disilicate discs in two shades (HT A2 and HT A4) and three different thicknesses (2, 4, and 6 mm) were bonded on dentine with preheated composite resin that was photo-polymerized for 20 s. The composite resin microhardness, the double bond conversion (DC) and their correlation were estimated.

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Nanofillers in resin materials can improve their mechanical and physicochemical properties. The present work investigated the effects of zirconia nanoparticles (NPs) as fillers in commercial dental luting cements. Two dual-cured self-adhesive composites and one resin modified glass ionomer (RMGI) luting cement were employed.

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Aim: This study examined if the classification systems for acute appendicitis could be applied in the emergency department as an indicator for surgical consultation, in order to reduce unnecessary paediatric surgery admission.

Methods: The Alvarado Score (ALS) and the Pediatric Appendicitis Score (PAS) were applied. The decisions for hospitalisation and treatment were made independent of the scores.

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Objectives: Phase angle (PA) constitutes a bioelectrical impedance measurement, indicating cell membrane health and integrity, hydration, and nutritional status. Handgrip strength (HS) has been also associated with body composition, nutritional status, inflammation, and functional ability in several chronic diseases. Although their prognostic significance as independent biomarkers has been already investigated regarding the outcomes of a cardiac surgery, our study is the first one to assess the combined predictive value of preoperative PA and HS.

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Article Synopsis
  • The 2016 MiECTiS position paper encouraged collaboration among cardiac surgeons, anesthesiologists, and perfusionists to establish a common language and framework for minimal invasive perfusion technologies.
  • Recent consensus updates confirm that modular minimal invasive extracorporeal circulation (MiECC) is a safe and effective technique for adult cardiac surgeries, enhancing biocompatibility and ensuring patient safety.
  • The MiECTiS supports MiECC as a multidisciplinary approach that significantly benefits patient care, urging its broader adoption to improve healthcare outcomes.
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Scrotal injuries are not very common in children and are mostly due to blunt trauma from direct injury, sports injuries or motor vehicle accidents. Traumatic testicular torsion in children has been also infrequently reported in the literature. To ensure testicular salvage, an urgent and specialised diagnosis and management are necessary.

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Article Synopsis
  • The study reviews outcomes of patients receiving mechanical circulatory support in Europe from 2011 to 2020, analyzing data from 72 hospitals with over 4,800 procedures included.
  • It found that in-hospital deaths and adverse events decreased significantly over three time eras, showing improvements in patient outcomes over time.
  • The research highlights that patient characteristics and risks associated with early versus late-phase outcomes are time-dependent, emphasizing the importance of continuous monitoring in clinical practices.
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Objective: To determine the influence of age on the ability of tracheal anastomoses to sustain distraction in dogs.

Study Design: Ex vivo study.

Sample Population: Cadaveric canine tracheae (n = 16).

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Background: This randomized controlled trial aimed to investigate the influence of physical activity and respiratory physiotherapy on zero postoperative day on clinical, hemodynamic and respiratory parameters of patients undergoing cardiac surgeries under extracorporeal circulation.

Methods: 78 patients undergoing coronary artery bypass graft (CABG) or/and valvular heart disease surgeries were randomly assigned into an early and enhanced physiotherapy care group (EEPC group; n = 39) and a conventional physiotherapy care group (CPC group; n = 39). Treatment protocol for the EEPC group included ≤3 Mets of physical activity and respiratory physiotherapy on zero post-operative day and an extra physiotherapy session during the first three post-operative days, whereas the CPC group was treated with usual physiotherapy care after the first post-operative day.

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Automatic amputation of the ovary represents a rather uncommon condition. Especially asymptomatic autoamputation is an even more unusual laparoscopic finding. We hereby present a case of a 2-days´-old infant with a prenatal ultrasound (US) diagnosis of a cystic mass, laparoscopically proved as an amputated right adnexa.

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