Publications by authors named "Anastasia Yuzhakova"
Membrane-embedded sensor histidine kinases (HKs) and chemoreceptors are used ubiquitously by bacteria and archaea to percept the environment, and are often crucial for their survival and pathogenicity. The proteins can transmit the signal from the sensor domain to the catalytic kinase domain reliably over the span of several hundreds of angstroms, and regulate the activity of the cognate response regulator proteins, with which they form two-component signaling systems (TCSs). Several mechanisms of transmembrane signal transduction in TCS receptors have been proposed, dubbed (swinging) piston, helical rotation, and diagonal scissoring.
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- Sensor histidine kinases are crucial transmembrane receptors in all life forms, but their signaling mechanisms remain largely unclear.
- The study presents detailed crystal structures of the NarQ sensor in both ligand-bound and unbound states, showcasing rearrangements in the transmembrane domain upon ligand binding.
- These findings enhance our understanding of two-component signaling systems and open pathways for designing new antimicrobial therapies targeting these systems.