Publications by authors named "Anastasia Roumpaki"
Article Synopsis
- Adult-onset Still's disease (AOSD) is a rare inflammatory condition that includes symptoms like daily fevers, joint pain, skin rashes, and spleen enlargement, often requiring tests to rule out blood cancers.
- A case study of a 38-year-old man revealed symptoms such as fatigue, high fever, night sweats, and skin rashes, leading to extensive testing, including CT and PET/CT scans that showed enlarged lymph nodes and high metabolic activity in his spleen and bone marrow.
- Ultimately, biopsies of the lymph node and bone marrow showed signs of hyperreactivity but no cancer, confirming AOSD as a diagnosis of exclusion, particularly when high ferritin levels and systemic symptoms are present
Endothelin-1 (ET-1) is a potent vasoconstrictor produced by endothelial cells and cleared from circulating blood mainly in the pulmonary vasculature. In a healthy pulmonary circulation, the rate of local production of ET-1 is less than its rate of clearance. In the present study, we aimed to investigate whether the abnormal pulmonary circulatory handling of ET-1 relates to poor clinical outcomes in patients with coronavirus disease 2019 (COVID-19)-induced acute respiratory distress syndrome (ARDS).
View Article and Find Full Text PDFArticle Synopsis
- Aging negatively impacts the endothelium, which is critical for vascular health, and the study focuses on endocan (ESM-1), a protein linked to endothelial function in critically ill patients.
- ESM-1 levels were found to be significantly higher in critically ill COVID-19 patients compared to non-septic and septic patients, and older septic patients had higher levels of ESM-1 compared to younger ones.
- The research revealed that while ESM-1 is a potential prognostic biomarker, its effectiveness varies with age and the degree of endothelial dysfunction, particularly in the younger septic patient demographic.