Publications by authors named "Anastasia Polozova"
Article Synopsis
- The research investigates how different types of glial tumors in rats affect the attenuation coefficient of white matter in the brain, showing varied impacts based on tumor type and malignancy.
- Some tumors lead to a significant drop in this coefficient due to cell infiltration and damage to myelinated fibers, while others compress fibers without major destruction.
- The study also highlights the potential of using the attenuation coefficient, derived from OCT data, to identify late radiation damage in white matter, suggesting its usefulness for evaluating tissue health around tumors during surgeries.
The phase of the cell cycle determines numerous aspects of cancer cell behaviour including invasiveness, ability to migrate and responsiveness to cytotoxic drugs. To non-invasively monitor progression of cell cycle in vivo, a family of genetically encoded fluorescent indicators, FUCCI (fluorescent ubiquitination-based cell cycle indicator), has been developed. Existing versions of FUCCI are based on fluorescent proteins of two or more different colors fused to cell-cycle-dependent degradation motifs.
View Article and Find Full Text PDFBiomeshes based on decellularized bovine pericardium (DBP) are widely used in reconstructive surgery due to their wide availability and the attractive biomechanical properties. However, their efficacy in clinical applications is often affected by the uncontrolled immunogenicity and proteolytic degradation. To address this issue, we present here multiparametric imaging analysis of epoxy crosslinked DBPs to reveal their fate after implantation.
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- Conventional diagnostic methods fail to adequately characterize the complex inner workings and diverse cell types in diseased livers during surgery, highlighting the need for better approaches.
- The research employs advanced technologies like multiphoton microscopy and mass spectrometry to study liver pathology, allowing for assessment of cellular metabolism and tissue composition without damaging samples.
- The findings from this combined method aim to improve the identification of liver diseases and create faster diagnostic techniques that can aid in surgical planning and reduce the risk of liver failure post-surgery.
The methods used for digital processing of optical coherence tomography (OCT) and crosspolarization (CP) OCT images are focused on improving the contrast ratio of native structural OCT images. Such advances are particularly important for the intraoperative detection of glioma margins where the visual assessment of OCT images can be difficult and lead to errors. The aim of the study was to investigate the application of optical coefficients obtained from CP OCT data for the differentiation of glial tumorous tissue from a normal brain.
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