Thioamides as radical scavenging compounds: Methods for screening antioxidant activity and detection.

Heteroaromatic thiols and thiones attracted the attention of chemists, pharmacologists and biochemists because of participation in the interception of free radicals. For the first time offered independent and reliable methods for evaluating of the antioxidant activity of thioamides-derivatives of pyridine, quinoline, imidazole, triazole, tetrazole, pyrimidine, pyrrolidine and 7-mercapto-4-methylcoumarin -based on kinetic parameters of the thioamide reaction with chromogenic radical (rate constant, M(-1)min(-1) and time to decrease concentration of test free radical by 50%, TEC50, min) or thermodynamics of the thioamides reaction with molecular iodine (extent of thioamide conversion, %). To compare the antioxidant activity of thioamides and widely used standard-antioxidant Trolox (6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid) we have proposed to use a value of relative antioxidant activity constant.

Synthesis and structure of interaction products of quinoline-2(1H)-thione with molecular iodine.

The behavior of quinoline-2(1H)-thione, which is a potential antithyroid drug toward molecular iodine, was investigated. The ability of quinoline-2(1H)-thione to form the outer-sphere charge-transfer complex C9H7NS·I2 with iodine molecular in dilute chloroform solution has been studied by UV-vis spectroscopy (lgβ=3.85).

Spectroscopic and structural investigation of interaction product of 8-mercaptoquinoline with molecular iodine.

The behavior of 8-mercaptoquinoline, which is a potential antithyroid drug toward molecular iodine was investigated. The ability of 8-mercaptoquinoline to form the outer-sphere charge-transfer complex C9H7NS·I2 with iodine molecular in dilute chloroform solution has been studied by UV/vis spectroscopy (lgβ=3.14).