Publications by authors named "Anastasia Lili"
Clin Pharmacokinet
July 2023
Article Synopsis
- The study focused on understanding the pharmacokinetics (PK) of pentobarbital, a medication often given to critically ill children with severe neurological conditions, using a population-based modeling approach.
- A one-compartment model was developed based on data from 36 patients and validated with a separate group of 9, revealing that kidney function and inflammation significantly affect drug clearance.
- The findings suggest that current dosing might lead to toxic levels in patients with elevated creatinine and C-reactive protein, highlighting the need for adjusted dosing strategies and further studies to improve safety and efficacy in this vulnerable population.
