Publications by authors named "Anastasia G Samoilova"
Introduction: The tuberculin skin test has significant limitations for use in individuals vaccinated with BCG. The presence in the genome of of the RDI region, which is absent in the genome of Mycobacterium bovis BCG and most non-tuberculous mycobacteria, made it possible to develop new skin tests, which include a skin test with a recombinant tuberculosis allergen [RTA (Diaskintest®, JSC Generium, Russia)]. Diaskintest has shown high diagnostic performance in clinical trials and in conditions of high prevalence of tuberculosis infection.
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- A study involving 5,340 residents of Moscow investigated the relationship between immune responses (antibodies and T cells) to SARS-CoV-2 and the likelihood of COVID-19 infection.* -
- Results showed that individuals with both high T-cell and antibody responses had the lowest risk of infection, while those with only an antibody response also had a strong protective effect.* -
- The findings highlight that antibody responses are more crucial for protection against SARS-CoV-2 compared to T-cell responses, suggesting potential implications for public health policies related to COVID-19.*
Background: After the breakup of the Soviet Union, the annual incidence of tuberculosis (TB) in children 15-17 years of age increased in the Russian Federation from 16 per 100 000 population in 1992 to 37 per 100 000 in 2009, and new control measures were implemented.
Methods: Children were screened annually for TB exposure with a tuberculin skin test (TST) at age 1-8 years. If positive, they were investigated for active TB.