Publications by authors named "Anastasia Dupre"
Article Synopsis
- Systemic lupus erythematosus is a disease that mainly affects young women, but pregnancies can be safe if the disease is managed well.
- Pregnancy poses more risks for these women compared to others, so careful planning and good advice before getting pregnant are really important.
- Doctors need to keep an eye on certain health factors that could lead to complications during pregnancy, and some treatments can safely continue to help manage lupus.
Background: The prevention of catastrophic antiphospholipid syndrome (CAPS), a rare complication of antiphospholipid syndrome (APS), is a major goal.
Objectives: We analyzed its precipitating factors, focusing on anticoagulation immediately before CAPS episodes.
Methods: We retrospectively analyzed patients in the French multicenter APS/systemic lupus erythematosus database with at least 1 CAPS episode.
Importance: Catastrophic antiphospholipid syndrome (CAPS) is a severe, rare complication of antiphospholipid syndrome (APS), but cutaneous involvement has not yet been adequately described.
Objective: To describe cutaneous involvement during CAPS, its clinical and pathological features, and outcomes.
Design, Setting, And Participants: This cohort study was a retrospective analysis of patients included in the French multicenter APS/systemic lupus erythematosus register (ClinicalTrials.
Article Synopsis
- The study aimed to identify distinct subgroups among APS patients using an unsupervised hierarchical cluster analysis to understand the diverse phenotypes of the disease.
- Researchers analyzed data from 509 APS patients who met specific criteria, identifying four patient clusters based on clinical and laboratory features: venous thromboembolism, arterial events with health issues, younger patients with additional autoimmune diseases, and severe cases with catastrophic symptoms.
- The findings suggest that APS is a heterogeneous disease with different underlying mechanisms, indicating the need for tailored treatments for each patient subgroup.
Objective: Primary Sjögren's syndrome (SS) is characterized by a lymphocytic infiltration of salivary glands (SGs) and the presence of an interferon (IFN) signature. SG epithelial cells (SGECs) play an active role in primary SS pathophysiology. We undertook this study to examine the interactions between SGECs and T cells in primary SS and the role of the interleukin-7 (IL-7)/IFN axis.
View Article and Find Full Text PDFObjective: Primary Sjögren's syndrome (pSS) is characterised by chronic hyperactivation of B lymphocytes. Salivary gland epithelial cells (SGECs) could play a role in promoting B-lymphocyte activation within the target tissue. We aimed to study the interactions between SGECs from patients with pSS or controls and B lymphocytes.
View Article and Find Full Text PDFObjective: Vedolizumab (VDZ) has been incriminated in the occurrence of articular manifestations in patients with inflammatory bowel diseases (IBDs). The aim of this study was to describe musculoskeletal manifestations occurring in IBD patients treated by VDZ and to identify risk factors.
Methods: In this retrospective monocentric study, we included all consecutive patients treated by VDZ for IBD in our hospital.