Immunologic Aspects in Fibrodysplasia Ossificans Progressiva.

Background: Inflammation is a major driver of heterotopic ossification (HO), a condition of abnormal bone growth in a site that is not normally mineralized.

Purpose Of Review: This review will examine recent findings on the roles of inflammation and the immune system in fibrodysplasia ossificans progressiva (FOP). FOP is a genetic condition of aggressive and progressive HO formation.

Fatty acid-binding proteins: functional understanding and diagnostic implications.

Purpose Of Review: Fatty acid-binding proteins (FABPs) are a family of small, abundant proteins with highly tissue-specific expression patterns whose different functions remain incompletely understood. The purpose of this review is to summarize recent findings regarding FABP functions and mechanisms of action, including their potential utilization as serum markers of tissue-specific metabolic diseases.

Recent Findings: FABPs are important not only in their tissues of origin but also appear to influence the metabolism and function of tissues distal to their sites of expression.

The Effectiveness of Mediterranean Diet in Nonalcoholic Fatty Liver Disease Clinical Course: An Intervention Study.

Diet is a modifiable key factor targeted in prevention and management of nonalcoholic fatty liver disease (NAFLD). The aim was to study the effect of Mediterranean Diet (MedDiet) on clinical, biochemical, and inflammatory profile in NAFLD patients with simple steatosis. Potential associations of signal transducer and activator of transcription 3 (STAT3) rs2293152 genotype to diet composition and patients' profile were investigated.

From Mediterranean diet to Mediterranean lifestyle: a narrative review.

Objective: To summarize the recent scientific evidence regarding the wellness-promoting capacity of the Mediterranean lifestyle (ML), with a special focus on physical, social and environmental wellness.

Design: Narrative review of English-language publications in PubMed, Scopus and Embase, from 1 January 2010 to 31 October 2018.

Setting: Prospective cohort studies, interventional studies, meta-analyses and reviews of those investigating the effect of at least one component of the ML on wellness parameters.

A modified response of NAFLD patients with non-significant fibrosis in nutritional counseling according to GCKR rs1260326.

Aim: To investigate the association between GCKR gene and nutritional treatment in NAFLD-related biomarkers.

Methods: This was an open-label and single-arm clinical trial in 44 overweight or obese adults with NAFLD receiving nutritional counseling for 6 months. Nutritional data, MedDietScore, clinical, biochemical, inflammatory and oxidative stress biomarkers were evaluated before and after intervention.