Identification and potency of cyclodextrin-lipid inhibitors of Staphylococcus aureus α-toxin.

Purpose: Staphylococcus aureus, a leading cause of bacterial keratitis, secretes α-toxin, a cytotoxin active on the corneal epithelium. This study describes the production and testing of chemical inhibitors of α-toxin action.

Methods: Purified α-toxin was titered by its ability to lyse rabbit erythrocytes in buffered saline (PBS).

Penetration and effectiveness of prophylactic fluoroquinolones in experimental methicillin-sensitive or methicillin-resistant Staphylococcus aureus anterior chamber infections.

Purpose: To determine the effectiveness of moxifloxacin and besifloxacin prophylactic therapy for experimental Staphylococcus aureus infections originating in the rabbit anterior chamber.

Setting: Microbiology Department, University of Mississippi Medical Center, Jackson, Mississippi, USA.

Design: Experimental study.