Modulating testosterone stimulated prostate growth by phenethyl isothiocyanate via Sp1 and androgen receptor down-regulation.

Background: The effects of phenethyl isothiocyanate (PEITC), present naturally in cruciferous vegetables, on androgen-influenced growth of the prostate such as benign hyperplasia, was investigated.

Methods: Rats dosed with cyproterone acetate and testosterone, were fed at the same time with either PEITC or vehicle control. The growth of the prostates was compared to untreated rats.

Epigenetic mechanism of growth inhibition induced by phenylhexyl isothiocyanate in prostate cancer cells.

Background: Isothiocyanates, the constituents of cruciferous vegetables, may be able to prevent prostate cancer. The hypothesis that they could remodel chromatins and activate cell cycle inhibitors, such as p21 for growth inhibition, was tested.

Materials And Methods: Prostate cancer LNCaP cells were exposed to phenylhexyl isothiocyanate (PHI).

Borrelia burgdorferi binds to, invades, and colonizes native type I collagen lattices.

Borrelia burgdorferi binds strongly to the extracellular matrix and cells of the connective tissue, a binding apparently mediated by specific proteins and proteoglycans. We investigated the interactions between B. burgdorferi cells and intact type I collagen using hydrated lattices that reproduce features of in vivo collagen matrices.