Publications by authors named "Anastacia Kudinova"
Article Synopsis
- Childhood adversity is associated with lasting psychological and physical health issues, including obesity and metabolic diseases, which can be linked to epigenetic changes.
- In a study involving two cohorts, researchers found that those with early life stress showed increased biological aging (measured by GrimAge Acceleration) and higher BMI and insulin resistance, particularly related to experiences of abuse.
- The findings suggest that epigenetic factors and the interactions with obesity might play key roles in understanding how childhood adversity impacts long-term health outcomes.
Objectives: We aimed to characterize the interplay between early life stress (ELS), metabolic syndrome (MetS), and plasminogen activator inhibitor-1 (PAI-1), a major inhibitor of the fibrinolytic system implicated in cardiometabolic diseases. We also examined the understudied intersection of ELS, physical activity and PAI-1.
Methods: Healthy young adults ages 18-40 (N=200; 68% female) were recruited from the community.
Article Synopsis
- - Sleep disruption is a significant public health issue for adolescents, and this study investigates how emotional experiences related to social media use affect sleep and mental health in psychiatrically hospitalized youth.
- - Involving 243 adolescents, the research found that negative emotional responses to social media were associated with increased sleep disturbances and severe clinical symptoms, such as suicidal thoughts and attention problems.
- - The study suggests that sleep disturbance may act as a mediator between negative emotional experiences on social media and clinical symptom severity, emphasizing the need for awareness around social media's impact on mental health in vulnerable youth populations.
Facial emotion recognition and mood symptom course in young adults with childhood-onset bipolar disorder.
Eur Arch Psychiatry Clin Neurosci
October 2021
Article Synopsis
- The study investigated how facial emotion recognition deficits are linked to mood symptoms in young adults with childhood-onset bipolar disorder (BD) compared to typically developing controls (TDCs).
- It found that individuals with BD made more mistakes in recognizing child emotional expressions, which correlated with their mood trajectories over time, impacting their levels of mania and depression.
- The results suggest that improving facial emotion recognition could be a valuable target for treatment and understanding of mood disorders in those with childhood-onset BD.
Article Synopsis
- Research indicates a connection between immune processes and psychological issues, particularly major depressive disorder (MDD), with a focus on specific symptoms like anhedonia rather than broad diagnostic categories.
- * A study examining immune responses to endotoxins in participants found that higher levels of current anhedonia were linked to increased inflammation, while a history of recurrent MDD did not show this association.
- * The results suggest that anhedonia may be a distinct symptom related to inflammation, making endotoxin-stimulated cytokine production a potential biological marker for current anhedonia.
Article Synopsis
- - Previous research has established that children and adolescents with bipolar disorder (BD) struggle with cognitive flexibility (CF), which involves adapting to changing rewards and punishments, but the link between CF and white matter microstructure in these youths hadn't been explored before.
- - This study used specific cognitive tests and advanced imaging techniques to find that the relationship between microstructural integrity of white matter and CF performance was significantly different in youth with BD compared to typically developing controls.
- - The findings suggest that there is an unusual relationship between CF and white matter in youths with BD, highlighting the need for more research to understand how these brain structures evolve over time in relation to CF and the progression of BD.
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder, and recurrent depression is associated with severe and chronic impairment. Identifying markers of risk is imperative to improve our ability to predict which individuals are likely to experience a recurrence. According to cognitive theories, biases in attention for affectively-salient information may serve as one mechanism of risk.
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- - The study explores how neighborhood crime, as a major environmental stressor, affects children's resting respiratory sinus arrhythmia (RSA), which is linked to emotional regulation and mental health risks.
- - Using a database to objectively measure neighborhood crime, the findings reveal that higher exposure to violent crime negatively impacts RSA levels in girls but not boys.
- - This research highlights the connection between high-crime environments and biological markers of emotion regulation, indicating that girls may be more vulnerable to the psychological effects of living in such neighborhoods.
Article Synopsis
- Maternal history of Major Depressive Disorder (MDD) significantly raises the likelihood of children developing depression, necessitating further investigation into how depression passes through generations.
- The study focused on how maternal MDD affects the emotional connection between mothers and their children during both positive (Vacation Planning) and negative (Issues Discussion) interactions, measuring real-time changes in facial expressions.
- Results indicated that mothers with a history of MDD showed less emotional synchronicity with their children, particularly during positive moments, which correlated with increased sadness reported by the children after discussions.