Cytokine and Chemokine Receptor Profiles in Adipose Tissue Vasculature Unravel Endothelial Cell Responses in HIV.

Chronic systemic inflammation contributes to a substantially elevated risk of myocardial infarction in people living with HIV (PLWH). Endothelial cell dysfunction disrupts vascular homeostasis regulation, increasing the risk of vasoconstriction, inflammation, and thrombosis that contribute to cardiovascular disease. Our objective was to study the effects of plasma from PLWH on endothelial cell (EC) function, with the hypothesis that cytokines and chemokines are major drivers of EC activation.

Transient ischemic dilatation with adenosine Tc-sestamibi stress: prognostic significance in patients with normal myocardial perfusion.

Objective: To determine the significance of transient ischemic dilatation (TID) in patients with normal perfusion on adenosine stress/rest.

Methods: We analyzed 430 consecutive patients with normal perfusion on 2-day adenosine stress/rest Tc-sestamibi. A group of 70 patients with Framingham 10-year coronary heart disease risk < 10% was used to derive abnormal TID thresholds (derivation group).