Publications by authors named "Anas AlYousef"

Article Synopsis
  • - The study investigates the differences in chronic kidney disease (CKD) management and characteristics between Kuwaiti citizens and expatriates, revealing that expatriates face restricted access to public health services and lower incomes, impacting their health outcomes.
  • - Data from 2,610 CKD patients showed that Kuwaitis were older with slightly lower kidney function (eGFR), but exhibited better blood pressure and diabetes control compared to expatriates, who had overall higher kidney function but poorer management of diabetes and hypertension.
  • - The conclusion emphasizes that CKD is predominantly caused by diabetes and hypertension, particularly in expatriates, and stresses the need for improved healthcare access, better treatment utilization, and more effective antihypertensive therapies for all patients.
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  • - Hyperkalemia, a condition common in heart failure and kidney disease patients using RAAS inhibitors, complicates their treatment; new potassium binders like sodium zirconium cyclosilicate show promise for managing this issue.
  • - A panel of twelve experts from Kuwait used a modified Delphi method to reach a consensus on hyperkalemia management, resulting in 44 statements covering treatments for acute cases, heart failure, chronic kidney disease, and hemodialysis.
  • - The consensus highlights the inconsistencies in current management guidelines and aims to provide standardized guidance for healthcare practitioners in Kuwait, addressing the treatment gaps in the Arabian Gulf region.
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  • The study investigates the incidence and outcomes of acute kidney injury (AKI) in Kuwait, focusing on differences between Kuwaiti and non-Kuwaiti patients, who face limited access to healthcare.
  • A total of 3,744 adult inpatients with AKI were analyzed from seven public hospitals in 2021, revealing that non-Kuwaitis were younger, had better kidney function at baseline, and a higher rate of AKI caused by community factors.
  • Despite differences in demographics, there were no significant variations in mortality or kidney recovery rates between the two groups, with a high overall mortality rate of 34.4% among AKI patients within 30 days of hospitalization.
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Article Synopsis
  • The study evaluates the cost-effectiveness of Sodium zirconium cyclosilicate (SZC) compared to patiromer in managing serum potassium levels in patients with chronic kidney disease (CKD) and heart failure (HF) from a Kuwaiti healthcare perspective.
  • A comprehensive simulation model was used to analyze the clinical outcomes and costs associated with both treatments over a lifetime horizon, using data from significant clinical trials and local hospital costs.
  • Results indicate that SZC is generally a cost-saving treatment option for managing hyperkalemia, with potential savings ranging from KWD -60 to KWD -1,235, suggesting it should be considered as a viable treatment for CKD/HF patients in Kuwait.
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Background: Iron deficiency is common in chronic kidney disease (CKD) patients not on dialysis (ND). Restoring depleted iron stores through intravenous (IV) route is faster and associated with less side effects. There is conflicting data regarding intravenous iron use and its impact on clinical outcomes in this population.

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Introduction: Hemodialysis (HD) patients are at increased risk of severe COVID-19 infection but infection rates vary. Our objectives are to describe COVID-19 positive HD patients' characteristics, infection rates, and factors associated with mortality in HD COVID-19 cases in Kuwait.

Methods: Data on demographics, comorbidities, and treatments received, as well as mortality for HD patients admitted to hospitals for COVID-19, from 1/March to 31/July 2020, prospectively collected and analyzed.

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Rationale & Objective: Chronic kidney disease-associated pruritus has been linked with poorer mental and physical health-related quality of life (HR-QOL) in patients receiving hemodialysis. We used the Skindex-10 questionnaire and a single itch-related question to evaluate their prediction of HR-QOL.

Study Design: Prospective, international cohort.

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Objectives: The aim of this study was to review the use rituximab (RTX) and outcomes in immune-mediated glomerular diseases (glomerulonephritis [GN]) and to compare it to the established literature.

Methods: Adult GN patients who received RTX between January 2014 and January 2018 in three public hospitals were reviewed. Membranous nephropathy (MN) and minimal change disease (MCD) were considered diseases with the literature supporting RTX use.

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Introduction: COVID-19 infection is associated with high mortality among hemodialysis patients. Standard vaccine response is generally lower among these patients. The adequate antibody titer response and the outcome of COVID-19 vaccine responders versus non-responders are unknown.

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The total number of end-stage kidney disease patients treated with dialysis in 2019 in Kuwait was 2230, with a 6% increase from the year before. Dialysis prevalence was 465 per million population (PMP) and dialysis incidence was100 PMP. Kuwaiti nationals represented 70% of the dialysis population and males represented 52%.

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Background: Glomerulonephritides (GN) are relatively rare kidney diseases with substantial morbidity and mortality. They are often difficult to treat, sometimes with no cure, and can lead to chronic kidney disease (CKD) and end stage kidney disease (ESKD). Kidney biopsy is the diagnostic procedure of choice with variable indications from center to center.

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Background: Dialysis adequacy, as measured by single pool , is an important parameter for assessing hemodialysis (HD) patients' health. Guidelines have recommended of 1.2 as the minimum dose for thrice-weekly HD.

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The prospective observational Dialysis Outcomes and Practice Patterns Study (DOPPS) was initiated in late 2012 in national samples of hemodialysis (HD) units (n = 41 study sites) in all six Gulf Cooperation Council (GCC) countries (Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, and the United Arab Emirates). For many years, guidelines have recommended single pool Kt/V ≥1.2 as the minimum adequate dose for chronic HD patients.

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Nutrition is an important factor in maintaining good health of hemodialysis (HD) patients, affecting their morbidity and mortality. The Dialysis Outcomes and Practice Patterns Study (DOPPS) is an international observational study assessing differences in dialysis practices and outcomes across >20 countries. Here, we present the results for the Gulf Cooperation Council (GCC) countries regarding nutrition data and its relationship with outcomes as a part of the DOPPS Phase 5 study (2012-2015).

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Kuwait has a small, relatively young population plagued with diabetes, hypertension, and obesity, making the risk of development and progression of chronic kidney disease (CKD) very high. The total dialysis population of Kuwait in 2015 was 1720. The Ministry of Health (MOH) has divided the country into six health regions.

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Peritoneal dialysis (PD) program was established in Farwaniya Hospital Kidney Center, Kuwait, in February 2011. Patient recruitment for this modality of treatment was growing steadily. One of the major complications of PD is peritonitis.

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Heparin-induced thrombocytopenia (HIT) is a type of drug-induced immune thrombocytopenia (DITP). DITP is a rare and challenging clinical issue, especially when it is associated with thrombosis. A 62-year-old woman was admitted to our institution with end-stage renal failure.

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