Ternary Cobalt (II)-Metformin-Glycine/Histidine/Proline Complexes: Multispectroscopic DNA, HSA, and BSA Interaction and Cytotoxicity Studies.

The synthesized water-soluble ternary complexes [Co(met)(gly)(Cl)] (1), [Co(met)(hist)(Cl)] (2), and [Co(met)(pro)(Cl)] (3), (met = metformin, gly = glycine, hist = histidine, and pro = proline) were evaluated using spectro-analytical techniques, and the stereochemistry of the complexes was determined to be octahedral. UV-Vis absorption, competitive DNA-binding experiments using ethidium bromide (EB) by fluorescence, fluorescence emission studies, viscosity studies, and gel electrophoresis techniques were all employed to explore the binding characteristics of the cobalt (II) complexes with CT-DNA and groove-binding mechanism established. The salt-dependent association of the complexes to CT-DNA was investigated using UV-Vis spectrophotometric analysis.

Metformin-Derived Water-Soluble Cobalt Complexes: Thermal, Spectroscopic, DNA Interaction, and Molecular Docking Studies.

Novel three water-soluble cobalt (II) complexes of type [Co(metf)(o-phen)]Cl (1), [Co(metf)(opda)]Cl (2), and [Co(metf)(2-2'bipy)]Cl (3) (Metf, metformin; o-phen, ortho-phenanthroline; opda, ortho-phenylenediamine; 2,2'-bipy, 2,2'-bipyridine) were synthesized and characterized by various analytical and spectral techniques. Based on these studies, octahedral geometry is assigned to these complexes. The stability of the complexes has been calculated from quantum chemical parameters using HOMO-LUMO energies.

Copper-metformin ternary complexes: Thermal, photochemosensitivity and molecular docking studies.

The copper(II) complexes [Cu(Cl)(met)(o-phen)] (1), [Cu(Cl)(met)(en)] (2) and [Cu(Cl)(met)(opda)] (3) (met = metformin, o-phen = ortho-phenanthroline, en = ethylenediamine, opda = ortho-phenylenediamine) were synthesized and characterized by LC-MS, elemental analysis, molar conductance, thermal analysis, infrared spectra, magnetic moment, electronic spectra and XRD studies. The metal center was found in an octahedral geometry. The activation thermodynamic properties were calculated using Coats-Redfern method.

Synthesis, characterization and antimicrobial activity of 3d transition metal complexes of a biambidentate ligand containing quinoxaline moiety.

A new series of oxovanadium(IV), chromium(III), manganese(II), iron(III), cobalt(II), nickel(II), and copper(II) complexes of the 3-hydrazino quinoxaline-2-one (HQO) were prepared and characterized. The ligand exhibits biambidenticity. It behaves as a bidentate ON donor in oxovanadium(IV), iron(III) and copper(II) complexes and as a bis bidentate ONNN donor in chromium(III), manganese(II), cobalt(II) and nickel(II) complexes.