Publications by authors named "Anannya Dhanwal"
Article Synopsis
- Tuberculosis (TB) remains a serious global health issue, highlighting the need for new treatments, especially against drug-resistant strains.
- This study focuses on lumazine synthase (RibH) as a key drug target for fighting Mycobacterium tuberculosis (M. tb), validating this approach using a CRISPRi gene knockdown strategy and high-throughput screening of over 600,000 compounds.
- Three identified compounds show strong antimycobacterial effects, reduce M. tb burden, enhance the effects of existing anti-TB drugs, and display favorable safety profiles, making RibH a promising target for future TB treatments.
