Publications by authors named "Anandakumar Anandakuttan"
Significance of elevated Prohibitin 1 levels in Multiple Sclerosis patients lymphocytes towards the assessment of subclinical disease activity and its role in the central nervous system pathology of disease.
Madathiparambil Kumaran Satheesh Kumar Sreepriya Nair Ullas Mony Sugavanan Kalingavarman Ramaswamynathan Venkat Anandakumar Anandakuttan
Int J Biol Macromol
April 2018
Article Synopsis
- MS is an autoimmune-neurodegenerative disorder where treating lymphocyte activity is key, with Prohibitin 1 (PHB) being significant in managing the disease due to its role in controlling reactive oxygen species (ROS).
- Recent studies show that PHB levels are significantly higher in both brain tissue of a mouse model for MS (EAE) and in the lymphocytes of MS patients during acute and relapsing phases compared to remission.
- The elevated PHB levels in these conditions suggest it could be a useful biomarker for evaluating disease status and predicting potential relapses in MS patients.