The Hemoglobin Wayne Variant and Association With Falsely Elevated HbA.

The objective of this work is to explain the effect of the clinically silent hemoglobinopathy hemoglobin Wayne (Hb Wayne) variant on glycated hemoglobin A (HbA) assay. This variant can result in falsely high HbA values among euglycemic individuals without diabetes mellitus (DM). We discuss 3 patients who were diagnosed with type 2 DM based on spuriously high HbA values due to the presence of Hb Wayne.