Variable responses of small and large human hepatocytes to hypoxia and hypoxia/reoxygenation (H-R).

Hypoxia and hypoxia-reoxygenation (H-R) regulate human hepatocyte cell death by mediating the accumulation of reactive oxygen species (ROS). Hepatocytes within the liver are organised into peri-portal (PP) and peri-venous (PV) subpopulations. PP and PV hepatocytes differ in size and function.

Acute liver failure due to primary angiosarcoma: a case report and review of literature.

Background: Hepatic angiosarcoma is a primary sarcoma of the liver, accounting for only 2% of all primary hepatic malignancies. Acute liver failure is an extremely rare presentation of a primary liver tumour.

Case Presentation: We report a case of a seventy year-old man who presented with a very short period of jaundice leading to fulminant hepatic failure (FHF).

Acute normovolemic hemodilution and intraoperative cell salvage in aortic surgery.

Objective: The objective of this study was to report current transfusion requirements and outcomes in patients undergoing elective aortic surgery with autologous transfusion.

Methods: This was a retrospective review of transfusion practice in infrarenal aortic surgery in a tertiary vascular unit with a longstanding interest in autologous transfusion. One hundred and ten consecutive patients underwent infrarenal aortic surgery with a combination of acute normovolemic hemodilution (ANH) and intraoperative cell salvage (ICS).