Assessment of cytotoxic and clastogenic effects of nimesulide: an NSAID drug in somatic cells of BALB/c mice in vivo.

The in vivo genotoxicity of nimesulide, a sulfononilide nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects, was evaluated by employing a mouse in vivo chromosomal aberration test in bone marrow cells. Oral treatment of animals for 5 consecutive days with 1, 2.5, 5, and 7.

Genotoxicity of crotonaldehyde in the bone marrow and germ cells of laboratory mice.

Genotoxicity of crotonaldehyde was evaluated by employing bone marrow and spermatocyte chromosomal aberration and dominant lethal mutation assays in Swiss albino mice. For bone marrow chromosomal aberration assay, animals were treated with 0.2ml olive oil containing 8, 16 and 32microl kg b.

In vivo evaluation of induction of abnormal sperm morphology in mice by an unsaturated aldehyde crotonaldehyde.

Crotonaldehyde, a highly reactive unsaturated aldehyde is used for the manufacture of sorbic acid, synthesis of butyl alcohol, butylaldehyde, quinaldine, thiophenes, pyridines, dyes, pesticides, pharmaceuticals, rubber antioxidants, chemical warfare agents, etc. and also occurs naturally in meat, fish, in many fruits and vegetables, bread, cheese, milk, beer, wine and liquors. Human exposure to crotonaldehyde occurs from both man-made and natural sources.

Genotoxicity of lomefloxacin--an antibacterial drug in somatic and germ cells of Swiss albino mice in vivo.

The in vivo genotoxicity of lomefloxacin, a diflourinated antibacterial drug, was evaluated by employing mouse in vivo chromosomal aberration test in bone marrow cells and dominant lethal mutation assay in germ cells. Statistically significant reduction in mitotic index, increase in chromosomal aberrations (CAs)/cell and percent abnormal metaphase was observed only at the highest dose (160 mg/kg b.w.

Mutagenic profiles of carbazole in the male germ cells of Swiss albino mice.

Mutagenic effect of carbazole was evaluated by employing dominant lethal mutation and sperm head abnormality assays in male Swiss albino mice. For the dominant lethal mutation assay, adult male mice were treated for five consecutive days either with 30 or 60 mg/kg body weight (b.w.