Taenia solium cysticerci's extracellular vesicles Attenuate the AKT/mTORC1 pathway for Alleviating DSS-induced colitis in a murine model.

The excretory-secretory proteome plays a pivotal role in both intercellular communication during disease progression and immune escape mechanisms of various pathogens including cestode parasites like Taenia solium. The cysticerci of T. solium causes infection in the central nervous system known as neurocysticercosis (NCC), which affects a significant population in developing countries.

Immunoinformatics Approaches for Vaccine Design: A Fast and Secure Strategy for Successful Vaccine Development.

Vaccines are major contributors to the cost-effective interventions in major infectious diseases in the global public health space [...

Wear rate and biocompatibility of pre and post UV irradiated UHMWPE for tribo-pair in total knee replacement application.

Ultra-high molecular weight polyethylene (UHMWPE) and CoCr alloy are popular tribo-pair in total knee replacement. Wear in the liner is a major failure reason for knee implant. Therefore, this work focuses on an approach for reducing the wear rate by irradiating the UHMWPE specimens using Ultraviolet (UV) radiation.

Immunoinformatics driven construction of multi-epitope vaccine candidate against using its entire immunogenic epitopes.

Objective: infects 80 million people per year, causing malnutrition, stunted growth of children etc., but there is no vaccine available against it. We aimed to design a multimeric-subunit vaccine using comprehensive immunoinformatic approach.

Vaccine for a neglected tropical disease cysticercosis: fight for eradication against all odds.

Introduction: infection is among the 17 most neglected tropical diseases identified by World Health Organization and to be eradicated by 2030. This parasite infects the central nervous system (Neurocysticercosis [NCC]) and intestine [Taeniasis]). NCC is the most frequent cause of acquired epilepsy in endemic regions and Taeniasis is responsible for the widespread malnutrition and abdominal discomfort among children.