Soluble Urokinase Plasminogen Activator Receptor: A Useful Marker for Predicting Mortality in COVID-19 Patients.

Introduction Efficient and practical healthcare based on prognostic indicators can reduce morbidity and mortality in hospitalized COVID-19 patients. Soluble urokinase plasminogen activator receptor (suPAR) predicts clinical outcomes and respiratory failure in SARS-CoV-2 patients, but additional research is needed. Among other characteristics, we aimed to evaluate the predictive value of suPAR in COVID-19 patients.

Repercussion of SARS-CoV-2 on the Sexual Function in Males Updated Review.

SARS-CoV-2, also called coronavirus causes SARS-CoV-2 or severe acute respir-atory syndrome, a highly transmissible disease that has rapidly spread worldwide, straining healthcare systems and leading to a substantial number of fatalities. Interestingly, SARS-CoV-2 has revealed a gender difference, with males dying at a greater rate and with more severe cases than women. It's worth noting that the male reproductive system might be par-ticularly susceptible to damage during periods of moderate to severe sickness, which has been linked to cases of orchitis and erectile dysfunction.

An expert consensus statement on biomarkers of ageing for use in intervention studies.

Biomarkers of ageing serve as important outcome measures in longevity-promoting interventions. However, there is limited consensus on which specific biomarkers are most appropriate for human intervention studies. This work aimed to address this need by establishing an expert consensus on biomarkers of ageing for use in intervention studies via the Delphi method.

Tranexamic Acid in Symptomatic Chronic Subdural Hematoma in the Absence of Surgical Intervention.

Background: Standard treatment for symptomatic chronic subdural hematoma (CSDH) is a burr-hole evacuation. However, in patients in whom surgical evacuation carries a very high risk, we do not have an established practice guideline.

Objective: To analyze the outcome of symptomatic CSDH treated only by tranexamic acid.

A Facile and Promising Delivery Platform for siRNA to Solid Tumors.

Over 20 years have passed since siRNA was brought to the public's attention. Silencing genes with siRNA has been used for various purposes, from creating pest-resistant plants to treating human diseases. In the last six years, several siRNA therapies have been approved by the FDA, which solely target disease-inducing proteins in the liver.

A new approach to overcome cytotoxic effects of Cu by delivering dual therapeutic ions (Sr, Cu).

Introduction: The incorporation of trace elements such as strontium (Sr) and copper (Cu) in the composition of mesoporous bioactive glass (MBG) is widely known to enhance its biological functionality for bone tissue regeneration METHODS: Two MBG powders with the composition 80SiO-11CaO-5PO-xCuO/SrO, one doped with 4 mol.% of CuO, the second with 4 mol.% of SrO were blended in the weight ratios of Cu-MBG: Sr-MBG; 100:0, 70: 30, 50: 50, 30: 70 and 0:100 aiming at minimizing Cu to minimize the cytotoxicity of Cu while preserving its antimicrobial activity.

Characterization of differentially regulated carboxypeptidase (metallopeptidase M32) protein in Miltefosine resistant Leishmania donovani parasites.

Introduction: Carboxypeptidase, a member of the metallopeptidase M32 family, catalyses the C-terminal hydrolysis of a variety of peptides and proteins in the presence of metal ions.

Objective: To characterize Leishmania donovani carboxypeptidase (LdCP) in miltefosine (MIL) drug-resistant parasites.

Methods: We performed the MTT assay and cell cycle analysis to confirm the MIL resistance of clinical isolates.

Atrial standstill in a young patient with ischemic stroke associated with inheritance of a novel HCN4 mutation.

We present a case of HCN4 gene mutation presenting with atrial standstill and stroke in the young.

Interplay of niche and respiratory network in shaping bacterial colonization.

The human body is an intricate ensemble of prokaryotic and eukaryotic cells, and this coexistence relies on the interplay of many biotic and abiotic factors. The inhabiting microbial population has to maintain its physiological homeostasis under highly dynamic and often hostile host environments. While bacterial colonization primarily relies on the metabolic suitability for the niche, there are reports of active remodeling of niche microenvironments to create favorable habitats, especially in the context of pathogenic settlement.

Survival and relapse patterns in patients of cranial vs extra-cranial oligometastases treated with stereotactic radiosurgery/stereotactic body radiation therapy and systemic therapy.

Objectives: To evaluate the outcome of patients with cranial (C) and extra-cranial (EC) oligometastases treated with stereotactic radiosurgery (SRS)/stereotactic body radiotherapy (SBRT) and standard of care systemic therapy.

Methods: During the period 2018-2022, patients who received SBRT or SRS for oligometastases (≤5 lesions) in addition to systemic therapy were evaluated. PET-CT was done to categorize them as C or EC oligometastases.

Assessment of the Bond Strength of Orthodontic Bracket on Ceramic Crown Surface Using Three Various Bonding Agents: A Comparative Study.

Aim: The current study's aim was to evaluate the orthodontic bracket's bond strength employing three different bonding agents on a ceramic crown surface.

Materials And Methods: Tooth preparation on 60 permanent maxillary premolar teeth extracted for orthodontic purposes was carried out. Supragingival finishing margins were made for all samples, and ceramic (PFM) crowns were fabricated.

Racial and ethnic disparities in alcohol-associated liver disease hospitalizations in Brazil before and after the COVID-19 pandemic.

Introduction And Objectives: The COVID-19 pandemic has resulted in a greater incidence of alcohol-associated liver disease (ALD) and simultaneously magnified health-related inequalities. We evaluated the impact of race and ethnicity on ALD-related hospitalizations in Brazil.

Materials And Methods: An interrupted time series analysis was used to estimate ALD-related hospitalization in public hospitals in Brazil.

Burnout, motivation and job satisfaction among community health workers recruited for a depression training in Madhya Pradesh, India: a cross-sectional study.

Introduction: Burnout, low motivation, and poor job satisfaction among community health workers (CHWs) have negative impacts on health workers and on patients. This study aimed to characterize levels of burnout, motivation, and job satisfaction in CHWs in Madhya Pradesh, India and to determine the relation between these levels and participant characteristics. This study can inform efforts to promote wellbeing and address stress in this population.

High-sensitivity cardiac troponin I and risk of dementia: 25-year longitudinal study in the Whitehall II cohort.

Objective: We hypothesise that subclinical myocardial injury during midlife, indexed by increases in cardiac troponin I, is associated with accelerated cognitive decline, smaller structural brain volume, and higher risk of dementia.

Design: Longitudinal cohort study.

Setting: Civil service departments in London (Whitehall II study).

Perioperative Outcomes and Feasibility of Single-Stage Laparoscopic Common Bile Duct Exploration (LCBDE) and Cholecystectomy With Internal Endo-Biliary Drainage for Management of Concomitant Cholelithiasis With Choledocholithiasis: A Report From a Tertiary Care Hospital.

Introduction: Managing choledocholithiasis alongside cholelithiasis has seen significant evolution, presenting options such as single-stage cholecystectomy with common bile duct (CBD) exploration, or a two-stage procedure involving endoscopic retrograde cholangiopancreatography (ERCP) performed before or after cholecystectomy. Evidence from Western settings may not fully capture the unique disease burden and demographic characteristics prevalent in developing countries. Laparoscopic common bile duct exploration (LCBDE) is more commonly performed in the Indian subcontinent compared to Western centers due to limited access to advanced procedures and specialized instrumentation for complex ERCP cases.

YOLO-I3D: Optimizing Inflated 3D Models for Real-Time Human Activity Recognition.

Human Activity Recognition (HAR) plays a critical role in applications such as security surveillance and healthcare. However, existing methods, particularly two-stream models like Inflated 3D (I3D), face significant challenges in real-time applications due to their high computational demand, especially from the optical flow branch. In this work, we address these limitations by proposing two major improvements.

Polyamine-Enriched Exosomes from Drive Host Macrophage Polarization via Immunometabolism Reprogramming.

() promastigotes secrete exosomes that are crucial in host-pathogen interactions and intercellular communication by carrying parasite-specific molecules. Although the composition of cargos in exosomes is known, the effects of the unique metabolic repertoire on immunometabolism rewiring of macrophage polarization are poorly understood. Interestingly, we found the enrichment of polyamines (PAs) such as spermidine and putrescine in the -exosomes.

An Unusual Case of a Stuck Catheter in a Sick Neonate.

The umbilical vein can be reliably used for central venous access in neonates less than 14 days old. The catheter used in the umbilical vein normally extends proximally to the inferior vena cava and can be utilized for drug delivery as well as venous sampling. Herein, we describe a neonate with a broken umbilical vein catheter (UVC) stuck in the right atrium and inferior vena cava (IVC), and its successful, uneventful removal via the transfemoral route.

Humanistic and Holistic Strategies for Combating Mental Health Sequelae in the Elderly During the Post-COVID Era.

Background: The elderly population is rapidly growing worldwide. By the year 2050, the elderly population will increase up to 2.1 billion.