Publications by authors named "Anamika Vikram"
Article Synopsis
- * Inhibition of ATGL using the human-specific inhibitor NG497 led to an increase in lipid droplet size and number in beta cells under glucose-sufficient conditions, while in alpha cells, the effect was more pronounced under fasting conditions, indicating ATGL's role in hormone secretion in both cell types.
- * Acute inhibition of ATGL reduced glucose-stimulated insulin secretion, particularly first-phase secretion, but to a lesser extent than chronic downregulation; NG497 also significantly lowered glucagon secretion at low
Knockdown (KD) of lipid droplet (LD) protein perilipin 2 (PLIN2) in beta cells impairs glucose-stimulated insulin secretion (GSIS) and mitochondrial function. Here, we addressed a pathway responsible for compromised mitochondrial integrity in PLIN2 KD beta cells. In PLIN2 KD human islets, mitochondria were fragmented in beta cells but not in alpha cells.
View Article and Find Full Text PDF