Vaccine
March 2022
Background: The Receptor Binding Domain (RBD) of the SARS-CoV-2 spike protein is the target for many COVID-19 vaccines. Here we report results for phase I clinical trial of two COVID-19 vaccine candidates based on recombinant dimeric RBD (d-RBD).
Methods: We performed a randomized, double-blind, phase I clinical trial in the National Centre of Toxicology in Havana.