Publications by authors named "Analise K Hofmann"
J Cell Biol
December 2017
Article Synopsis
- The study investigates how proteins involved in DNA repair and cellular stress responses change their location in the cell during genotoxic stress, focusing on the splicing factor Hsh155.
- Hsh155 moves away from its usual partners and accumulates in specific protein quality control aggregates in both the nucleus and cytoplasm when exposed to alkylation stress, a process influenced by molecular chaperones and TORC1 signaling.
- This relocalization of Hsh155 is linked to changes in gene expression, including increased intron retention and reduced splicing efficiency, ultimately aiding the cell's recovery from stress.
