Publications by authors named "Analise Hofmann"

Instructors can deliberately design for equity, diversity, and inclusion, including for large first-year classes, and now instructors have added challenges given COVID-19. Our paper explores the question: How do we integrate equity, diversity, and inclusion and universal design for learning (UDL) into first-year, undergraduate ecology and evolution introductory lessons given the COVID-19 pandemic? Given the large field exploring equity, diversity, and inclusion, we chose to focus on developing reflective practice question rubrics for before, during, and after lessons to encourage UDL for instructors, teaching assistants, and learners. We conducted a focus group within our team and discussed ideas related to online learning, including related pitfalls and solutions.

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Stress granules (SGs) are stress-induced membraneless condensates that store non-translating mRNA and stalled translation initiation complexes. Although metazoan SGs are dynamic compartments where proteins can rapidly exchange with their surroundings, yeast SGs seem largely static. To gain a better understanding of yeast SGs, we identified proteins that sediment after heat shock using mass spectrometry.

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Article Synopsis
  • The study investigates how proteins involved in DNA repair and cellular stress responses change their location in the cell during genotoxic stress, focusing on the splicing factor Hsh155.
  • Hsh155 moves away from its usual partners and accumulates in specific protein quality control aggregates in both the nucleus and cytoplasm when exposed to alkylation stress, a process influenced by molecular chaperones and TORC1 signaling.
  • This relocalization of Hsh155 is linked to changes in gene expression, including increased intron retention and reduced splicing efficiency, ultimately aiding the cell's recovery from stress.
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