Clinical repercussions in pertussis infants post-Tdpa vaccination of pregnant woman: An immunization success?

Introduction: In 2014, there was an epidemic of pertussis in Brazil that caused the death of 129 infants. To control the disease amongst infants under 6 months of age, and especially those under 2 months, the Brazilian Ministry of Health introduced Tdap immunization for all pregnant women.

Methods: This study aimed to describe the morbidity and mortality variables of pertussis cases in 969 infants aged under 6 months, comparing the periods before and after the introduction of Tdap vaccine in pregnant women.

Protective effect of exclusive breastfeeding and effectiveness of maternal vaccination in reducing pertussis-like illness.

Objective: To assess the protective effect of exclusive breastfeeding and the effectiveness of maternal vaccination in reducing pertussis-like illness.

Method: This was a case-control study conducted in sentinel hospitals for pertussis in Recife between July 2016 and July 2018. Cases included children aged under six months with symptoms compatible with pertussis (pertussis-like illness).

Pertussis may be the cause of prolonged cough in adolescents and adults in the interepidemic period.

Objective: This study was aimed to evaluate the prevalence of pertussis in adolescents and adults with cough lasting more than 14 days and less than 30 days.

Methods: This is a prospective observational study in interepidemic period of pertusis. Ten public health outpatient clinics in the city of Recife, Brazil, were randomly selected for the study.

Pertussis vaccine effectiveness in reducing clinical disease, transmissibility and proportion of cases with a positive culture after household exposure in Brazil.

In household outbreaks of pertussis, children <5 years of age who received at least 3 doses of vaccine had 12% less clinical disease; vaccinated cases were 63% less culture-confirmed and transmitted infection to 62% fewer contacts. Three doses of pertussis vaccine are likely to decrease circulation of Bordetella pertussis by reducing the proportion of bacteriologically positive cases and transmissibility.