Publications by authors named "Anais Millet"
Microbubble (MB)-assisted ultrasound (US) is an innovative modality for the non-invasive, targeted, and efficient delivery of therapeutic molecules into the brain. Previously, we reported the first metabolomic signature of blood-brain barrier opening (BBBO) induced by MB-assisted US. In the present study, the neurometabolic consequences of acoustically-mediated BBBO on cerebral tissue were investigated using multimodal metabolomics approaches.
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- * A study using rats showed that this method led to a reversible opening of the blood-brain barrier without harming the brain or affecting the animals' weight and behavior.
- * Metabolomic analyses indicated significant changes in metabolic processes, particularly in blood serum, with specific perturbations in arginine and tryptophan metabolism linked to vascular inflammation and neurotransmission impacts.