Publications by authors named "Anais Dupont"
Article Synopsis
- Various Gram-negative bacteria in the oral cavity produce β-lactamases, which are enzymes that confer resistance to β-lactam antibiotics, and they belong to different classes of the Ambler classification.
- The variability in β-lactam effectiveness is often linked to the presence of plasmids and mobile genetic elements that influence resistance gene expression.
- The oral cavity serves as a significant reservoir for β-lactam resistance genes, supported by mechanisms like genetic transformation and efflux pump overexpression, highlighting the role of commensal anaerobic bacteria in antibiotic resistance.
The aim of this study was to use the near-infrared spectroscopy (NIRS) as a process analytical tool to evaluate the conformity of paracetamol tablets in terms of four Pharmacopoeia tests (content uniformity, hardness, disintegration time, friability) and to control in-line blend uniformity. Tablets were manufactured by direct compression. Three different active pharmaceutical ingredient (API) concentrations were manufactured and three different compaction pressures were used.
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