Publications by authors named "Anais Assouvie"
Radiotherapy (RT) triggers an immune response that contributes to anti-tumor effects. Induction of interferon beta (IFN-β) is a key event in this immunogenicity of RT. We have previously shown that TRIM33, a chromatin reader, restrains IFN-β expression in Toll-like receptor-activated myeloid cells.
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- Tumor cells heavily depend on glycolysis for energy, making immunotherapy more effective against tumors with low glycolysis and less lactate dehydrogenase (LDH) activity, leading to better glucose availability for immune cells.* ! -
- Inhibiting LDH reduces glucose uptake and growth in tumor cells while increasing glucose uptake and activity in tumor-infiltrating T cells, improving their ability to kill tumors and counteracting immunosuppression.* ! -
- Combining LDH inhibitors with immune checkpoint therapies shows promising results in controlling cancer progression by enhancing T cell activity and weakening regulatory T cell functions in mouse models of melanoma and colon cancer.* !
Interferon β (IFN-β) is a cytokine that induces a global antiviral proteome, and regulates the adaptive immune response to infections and tumors. Its effects strongly depend on its level and timing of expression. Therefore, the transcription of its coding gene IFNB1 is strictly controlled.
View Article and Find Full Text PDFBone marrow-derived macrophages (BMDM) are primary macrophages obtained by in vitro differentiation of bone marrow cells in the presence of macrophage colony-stimulating factor (M-CSF or CSF1). They are easy to obtain in high yields, can be stored by freezing, and can be obtained from genetically modified mice strains. They are therefore widely used as prototypical macrophages for in vitro studies.
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