Publications by authors named "Anahita Shiva"
Article Synopsis
- Post-thrombotic syndrome (PTS) is a frequent complication following deep vein thrombosis (DVT), affecting 20-50% of patients and leading to a lower quality of life, with limited effective clinical predictors available for assessing PTS risk.
- A pilot study investigated the neutrophil-to-lymphocyte ratio (NLR), an indicator of systemic inflammation, as a potential predictive biomarker for PTS in patients diagnosed with iliofemoral DVT.
- The study found that an NLR cut-off of 7.71 could significantly predict PTS, with 36.44% of patients experiencing the syndrome, suggesting that NLR could be a useful tool in evaluating PTS risk alongside other clinical markers.
Improving the management of metastasis in pancreatic neuroendocrine tumors (PanNETs) is critical, as nearly half of patients with PanNETs present with liver metastases, and this accounts for the majority of patient mortality. We identified angiopoietin-2 (ANGPT2) as one of the most upregulated angiogenic factors in RNA-Seq data from human PanNET liver metastases and found that higher ANGPT2 expression correlated with poor survival rates. Immunohistochemical staining revealed that ANGPT2 was localized to the endothelial cells of blood vessels in PanNET liver metastases.
View Article and Find Full Text PDFUnlabelled: T-cell position in the tumor microenvironment determines the probability of target encounter and tumor killing. CD8+ T-cell exclusion from the tumor parenchyma is associated with poor response to immunotherapy, and yet the biology that underpins this distinct pattern remains unclear. Here we show that the vascular destabilizing factor angiopoietin-2 (ANGPT2) causes compromised vascular integrity in the tumor periphery, leading to impaired T-cell infiltration to the tumor core.
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