Tailoring the release rates of fluconazole using solid dispersions in polymer blends.

Formulations of the drug Fluconazole with different release characteristics were prepared by dispersing the active pharmaceutical ingredient (API) in various polymeric carriers, and especially in polymer blends. Fluconazole was tested as a model drug with low solubility in water. First solid dispersions in pure polymers were studied.

Effect of physical state and particle size distribution on dissolution enhancement of nimodipine/PEG solid dispersions prepared by melt mixing and solvent evaporation.

The physical structure and polymorphism of nimodipine were studied by means of micro-Raman, WAXD, DSC, and SEM for cases of the pure drug and its solid dispersions in PEG 4000, prepared by both the hot-melt and solvent evaporation methods. The dissolution rates of nimodipine/PEG 4000 solid dispersions were also measured and discussed in terms of their physicochemical characteristics. Micro-Raman and WAXD revealed a significant amorphous portion of the drug in the samples prepared by the hot-melt method, and that saturation resulted in local crystallization of nimodipine forming, almost exclusively, modification I crystals (racemic compound).

Variable Coordination and Conformation of the 3-Cyano-2,4-pentanedionato Anion in a Mixed-Ligand Binuclear Copper(II) Chelate.

The addition of dipyridylamine to bis(3-cyano-2,4-pentanedionato)copper(II), Cu(NC-acac)(2), induces changes in the mode of interaction and the conformation of the NC-acac(-) anion. The structure of the resulting binuclear compound was determined from a single microcrystal (monoclinic, space group P2(1), a = 7.894(7) Å, b = 25.