Publications by authors named "Anagi Wickremasinghe"
Background: Gastro-esophageal reflux (GORD) following sleeve gastrectomy (SG) is a central challenge, and precise indications for revisional surgery or the physiology have not been precisely defined. We aimed to determine whether OAGB performed for reflux post-SG (1) accelerates gastric emptying half-time, (2) reduces the frequency and severity of reflux events, and (3) improves reflux symptoms.
Methods: We undertook a prospective trial (ACTRN12616001089426).
Article Synopsis
- The study examines weight loss issues following laparoscopic sleeve gastrectomy (LSG) by comparing gastric emptying rates through nuclear scintigraphy and CT volumetric imaging among patients categorized by their weight loss success.* -
- Results showed that patients with optimal weight loss (OWL) experienced a significantly greater percentage of total weight loss and faster gastric emptying compared to those with poor weight loss (PWL), indicating delayed gastric emptying is linked to less weight loss effectiveness.* -
- The findings suggest that nuclear scintigraphy could be a more reliable diagnostic tool for assessing physiological function post-LSG than measuring gastric volume, as the latter did not correlate with weight loss outcomes.*
Background: Significant controversy exists regarding the indications and outcomes after laparoscopic adjustable gastric banding (LAGB) conversions to laparoscopic sleeve gastrectomy (LSG).
Aim: To comprehensively determine the long-term outcomes of sleeve gastrectomy as a revisional procedure after LAGB across a range of measures and determine predictors of outcomes.
Methods: Six hundred revision LSG (RLSG) and 1200 controls (primary LSG (PLSG)) were included.
Purpose: There are significant alterations in gastro-intestinal function, food tolerance, and symptoms following sleeve gastrectomy (SG). These substantially change over the first year, but it is unclear what the underlying physiological basis for these changes is. We examined changes in oesophageal transit and gastric emptying and how these correlate with changes in gastro-intestinal symptoms and food tolerance.
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- Stress urinary incontinence (SUI) and pelvic organ prolapse (POP) are common pelvic floor disorders, prompting the establishment of the Australasian Pelvic Floor Procedure Registry (APFPR) to track and improve the outcomes of surgeries involving these conditions.
- The registry follows national standards for clinical quality, using a modified Delphi process to create a dataset and collects data primarily from participating surgeons, while also incorporating patient-reported outcome measures (PROMs).
- As of January 2023, the APFPR has 32 active sites across Australia for patient recruitment, with some sites already collecting data and others in the governance approval process.
Background: Intermediate to long-term weight regain is a major challenge following sleeve gastrectomy (SG). Physiological changes that mediate the extent of weight loss remain unclear. We aimed to determine if there were specific esophago-gastric transit and emptying alterations associated with weight regain.
View Article and Find Full Text PDFObjective: To evaluate the mechanisms associated with reflux events after sleeve gastrectomy (SG).
Summary Background Data: Gastro-esophageal reflux (GERD) post-SG is a critical issue due to symptom severity, impact on quality of life, requirement for reoperation, and potential for Barrett esophagus. The pathophysiology is incompletely delineated.
Purpose: Sleeve gastrectomy (SG) patients have substantially altered anatomy. The mechanism of rapid gastric emptying and the role of esophageal contractile function in esophago-gastric transit has not been defined. We aimed to determine the mechanisms of esophago-gastric transit and role of esophageal function following sleeve gastrectomy.
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