Bioassay guided fractionation, isolation and characterization of hepatotherapeutic 1, 3-di-ortho-galloyl quinic acid from the methanol extract of the leaves of Pterocarpus santalinoides.

Ethnopharmacological Relevance: Leaf extracts of Pterocarpus santalinoides DC are traditionally used to ameliorate ageing-related ailments such as heart and liver diseases, and have been reported to be protective against toxic injuries to the liver.

Aim Of The Study: This study aimed to isolate and characterize the hepatoprotective/hepatotherapeutic principle in the methanol leaf extract of P. santalinoides.

Effects of Controlled Generator Fume Emissions on the Levels of Troponin I, C-Reactive Protein and Oxidative Stress Markers in Dogs: Exploring Air Pollution-Induced Cardiovascular Disease in a Low-Resource Country.

Exhaust fumes from petrol/diesel-powered electric generators contribute significantly to air pollution in many developing countries, constituting health hazards to both humans and animals. This study evaluated the serum concentrations of Troponin I (TnI), C-reactive protein (CRP) and serum levels/activities of oxidative stress markers: catalase (CAT), reduced glutathione (GSH), malondialdehyde (MDA), nitric oxide (NO) and superoxide dismutase (SOD) in dogs experimentally exposed to graded levels of petrol generator exhaust fume (PGEF). Sixteen (16) healthy and adult male Basenji dogs were randomly assigned into four groups (A-D).

Potential antidiabetic and antioxidant activities of a heliangolide sesquiterpene lactone isolated from Helianthus annuus L. leaves.

Heliangolide is a naturally occurring sesquiterpene lactone and its derivatives are biologically active compounds present in most medicinal plants. This study evaluated the antioxidant and antidiabetic properties of a heliangolide sesquiterpene lactone isolated from Helianthus annuus L. leaves.

Ameliorative Effects of Helianthus Annuus Against Nephrotoxic, Cardiac, and Haematological Disorders in Alloxan-induced Hyperglycaemia in Albino Rats.

Introduction: The study evaluated the ameliorative effects of leaf extract on nephrotoxicity, cardiac, and haematologic disorders in alloxan-induced hyperglycaemic rats.

Material And Methods: The cold maceration method with 80% methanol was used in the preparation of . extract.

Antidiabetic, antilipidemic, and antioxidant activities of Gouania longipetala methanol leaf extract in alloxan-induced diabetic rats.

Context: Gouania longipetala Hemsl. (Rhamnaceae) is used in folkloric medicine for treating diabetes mellitus and its associated symptoms.

Objective: This study evaluated the antidiabetic antilipidemic and antioxidant activities of the plant methanol leaf extract.

Acute and sub-chronic toxicity profile of methanol leaf extract of Gouania longipetala in rats.

Ethnopharmacological Relevance: Gouania longipetala leaves are commonly used in folkloric medicine in Africa and other parts of the world for treatment of edema, febrifuges, veneral diseases, lumbago, heart diseases, diabetes mellitus malaria, etc. This study therefore evaluated safety profile of the methanol leaf extract of the plant using acute and sub-chronic studies in rat model.

Materials And Methods: Acute toxicity test of the plant lasted for 48 h with oral administration of graded doses (100-4000 mg/kg) of Gouania longipetala extract (GLE) in rats.

Anti-ulcerogenic activity of the methanol root bark extract of Cochlospermum planchonii (Hook f).

Cochlospermum planchonii (Hook f) is a common medicinal plant used in Nigeria traditional medicine for treatment of different ailments including ulcers. The anti ulcer activity of the root bark methanol extract of Cochlospermum planchonii was evaluated using different [ethanol, acetylsalicylic acid (aspirin), cold/restraint stress and pyloric ligation/histamine - induced ulcers and acid production] ulcerogenic models in rats at the doses of 250, 500, and 1000 mg/kg body weight using cimetidine (100 mg/kg) as a standard reference drug. The different doses of the extract and the reference drug significantly (p < 0.

Acute toxicity and hepatotoxicokinetic studies of Tamarindus indica extract.

Tamarindus indica is widely used as a food and beverage and in traditional medicine. The apparent lack of dose standardization in herbal medicine necessitates the evaluation of the lethality T. indica on Artemia salina nauplii and chicken embryos via in vitro and in vivo techniques.

The effects of combination of methanolic leaf extract of Azadirachta indica and diminazene diaceturate in the treatment of experimental Trypanosoma brucei brucei infection in rats.

Objective: To investigate the effects of combination therapy of methanolic leaf extract of Azadirachta indica (A. indica) and diminazene diaceturate (DDA) in the treatment of experimental Trypanosoma brucei brucei (T. brucei brucei) infection in rats.

Glucose uptake-enhancing activity of the ethyl acetate extract of Dennettia tripetala in 3T3-L1 adipocytes.

Glucose uptake-enhancing activity of the ethyl acetate extract of Dennettia tripetala (EDT) was investigated using 3T3-L1 adipocytes. EDT yielded 4.43 percent w/w dry matter, showed the presence of alkaloids and flavonoids, contained calcium, iron, zinc, magnesium, copper and manganese.

Investigations of the methanolic leaf extract of Costus afer. Ker for pharmacological activities in vitro and in vivo.

The methanolic leaf extract of Costus afer. Ker (family: Zingiberaceae) was investigated for some pharmacological effects in vivo and in vitro. Brine shrimp lethality test showed that the extract was significantly (p < 0.

Preliminary physicochemical evaluations and bioactive properties of column fractions from the lichen.

The chloroform-soluble portion of an ethanolic extract of the lichen Ramalina farinacea was separated by column chromatography using n-hexane: ethylacetate (4:1) as the mobile phase and silica gel S as the stationary phase. Four column fractions (B, C, H and I) and the n-hexane-soluble portion of the ethanolic extract (N) were screened for possible biological activity by the Brine Shrimp Lethality Bioassay Technique. Some physicochemical evaluations of the column fractions such as pH determinations, ultraviolet (UV) absorption spectra, solubility profile and some chemical tests were also carried out.