Publications by authors named "Anaelle A Dumas"
Beyond borders: the choroid plexus-immune communication during neuroinflammation.
Signal Transduct Target Ther
October 2024
Article Synopsis
- Scientists are studying how some special processes in brain cell development, called epigenetics, are linked to changes in a type of brain cancer called glioblastoma (GBM).
- They developed a way to compare cells from glioblastoma with special brain stem cells from patients to find important differences.
- This research helps identify new ways to treat GBM by finding specific genes that can be targeted with drugs based on each patient's unique cancer.
As resident macrophages of the central nervous system (CNS), microglia are associated with diverse functions essential to the developing and adult brain during homeostasis and disease. They are aided in their tasks by intricate bidirectional communication with other brain cells under steady-state conditions as well as with infiltrating peripheral immune cells during perturbations. Harmonious cell-cell communication involving microglia are considered crucial to maintain the healthy state of the tissue environment and to overcome pathology such as neuroinflammation.
View Article and Find Full Text PDFMicroglial cells perform a plethora of functions in the central nervous system (CNS), involving them in brain development, maintenance of homeostasis in adulthood, and CNS diseases. Significant technical advancements have prompted the development of novel systems adapted to analyze microglia with increasing specificity and intricacy. The advent of single-cell technologies combined with targeted mouse models has been decisive in deciphering microglia heterogeneity and dissecting microglial functions.
View Article and Find Full Text PDFGlioblastoma (GBM) is the most common and aggressive intrinsic brain tumour in adults. Epigenetic mechanisms controlling normal brain development are often dysregulated in GBM. Among these, BMI1, a structural component of the Polycomb Repressive Complex 1 (PRC1), which promotes the H2AK119ub catalytic activity of Ring1B, is upregulated in GBM and its tumorigenic role has been shown and .
View Article and Find Full Text PDFArticle Synopsis
- Microglia are special cells in the brain that help keep everything balanced, but as mice (and people) get older, these cells can become more easily triggered by things that cause inflammation.
- In older mice, a system called mTOR is more active, which makes proteins that can lead to inflammation to be produced more.
- When scientists turned off the mTOR system, the mice showed less inflammation and sickness, even though some genes related to inflammation were still increased, suggesting that mTOR plays an important role in how microglia react as we age.
Article Synopsis
- Tumour-associated microglia/macrophages (TAM) are the most common types of cells found in brain tumors called glioblastoma multiforme (GBM).
- A pathway called mTOR, which helps control how cells survive and grow, is more active in these tumors, and researchers are studying how it affects TAM.
- Their findings suggest that mTOR makes microglia less helpful in fighting the tumor, allowing it to grow and escape the immune system, and they believe targeting mTOR in microglia could be more effective than focusing only on tumor cells.
Huntington's disease is caused by a CAG repeat expansion in exon 1 of the HTT gene. We have previously shown that exon 1 HTT does not always splice to exon 2 producing a small transcript (HTTexon1) that encodes the highly pathogenic exon 1 HTT protein. The mechanisms by which this incomplete splicing occurs are unknown.
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