Publications by authors named "Anael Cain"
Article Synopsis
- Researchers created a comprehensive cell atlas of the aging brain by analyzing 1.65 million single-nucleus RNA sequences from older adults, revealing specific cell types linked to Alzheimer’s disease (AD).
- They discovered two distinct microglial subpopulations involved in the progression of amyloid-β and tau proteinopathies, as well as an astrocyte subpopulation linked to cognitive decline.
- Using a new methodology called BEYOND, the study identified two different pathways of brain aging, which helps in developing personalized therapies targeting specific cellular communities related to AD and other forms of brain aging.
Article Synopsis
- Researchers created a detailed cellular map of the aging frontal cortex using single-nucleus RNA sequencing from 24 individuals to understand cell interactions in Alzheimer's disease (AD).
- The study identified various cell populations linked to AD, such as a specific type of inhibitory neuron and different states of oligodendrocytes, and highlighted changes in two distinct multicellular communities in AD.
- By analyzing these cellular changes, the research aims to uncover how alterations contribute to cognitive decline, laying the groundwork for future studies on the cellular environments related to AD and dementia.
Article Synopsis
- Alzheimer's Disease (AD) is a progressive brain disorder linked to aging, and recent research has created a detailed cell atlas of the prefrontal cortex to understand its cellular dynamics.
- The study identified specific cell populations that contribute to AD, including two types of microglia associated with amyloid-β and tau proteins, and an astrocyte subpopulation linked to cognitive decline.
- The researchers developed a methodology called BEYOND to reveal two aging trajectories in older individuals, providing insights that could lead to new treatments and management strategies for AD and alternative brain aging.
Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.
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