Publications by authors named "Anabel de la Barrera"
Article Synopsis
- The interaction between IL-2 and IL-2R is crucial for the development and maintenance of T regulatory (Treg) cells, but mice lacking these proteins still have some immature Treg cells.
- Mice lacking the common gamma chain (gammac) show a nearly complete absence of Treg cells, suggesting that other gammac-cytokines, like IL-7 and IL-15, play important roles in Treg cell development.
- The study indicates that both IL-2 and IL-7 signaling are essential for the production of mature Treg cells, with IL-2Rbeta being the most critical for restoring Treg cell production in deficient mice.
