Publications by authors named "Anabel M Ruiz-Mateos"
JCI Insight
September 2022
Article Synopsis
- The study investigated the immune responses to the SARS-CoV-2 vaccine in individuals over and under 60, revealing that older adults had lower antibody levels and a weaker T cell response.
- Aging resulted in decreased thymic function and T cell quality, leading to ineffective immune responses two months post-vaccination in those over 60.
- Additionally, issues with dendritic cell function and a proinflammatory profile in monocytes were linked to the diminished specific T cell responses observed in the older age group, suggesting improvements could enhance vaccine effectiveness for this population.
